Hu Johnny, Launay Jean-Pierre, Chaumont Alain, Heitz Valérie, Jacquot de Rouville Henri-Pierre
LSAMM, Institut de Chimie de Strasbourg, CNRS UMR 7177, Université de Strasbourg, 4, rue Blaise Pascal, 67000, Strasbourg, France.
CEMES-CNRS, Université de Toulouse, 29 rue Jeanne Marvig, 31055, Toulouse, France.
Chemistry. 2024 Aug 6;30(44):e202401866. doi: 10.1002/chem.202401866. Epub 2024 Jul 15.
Protonated and methylated bis-acridinium tweezers built around a 2,6-diphenylpyridyl and an electron enriched 2,6-di(p-anisyl)pyridyl spacer have been synthesized. These tweezers can self-assemble in their corresponding homodimers and the associated thermodynamic parameters have been probed in organic solvents. The switching properties of the tweezers have been exploited in biphasic transfer experiments showing the shift of the equilibria towards the homodimers. Moreover, the thermodynamic parameters of the formation of the reduced methylated homodimers investigated by electrochemical experiments revealed the dissociation of the dimers. Thus, in addition to solvent and temperature, the pH and redox responsiveness of the acridinium units of the tweezers make it possible to modulate to a larger extent the monomer-dimer equilibria.
围绕2,6 - 二苯基吡啶基和富电子的2,6 - 二（对甲氧基苯基）吡啶基间隔基构建的质子化和甲基化双吖啶鎓镊子已被合成。这些镊子可以自组装成相应的同二聚体，并在有机溶剂中探究了相关的热力学参数。镊子的开关特性已在双相转移实验中得到应用，显示出平衡向同二聚体的转移。此外，通过电化学实验研究的还原甲基化同二聚体形成的热力学参数揭示了二聚体的解离。因此，除了溶剂和温度外，镊子中吖啶鎓单元的pH值和氧化还原响应性使得能够在更大程度上调节单体 - 二聚体平衡。
