Li Guoshuai, Yan Yifei, Tang Jinghong, Ma Qingxue, Huang Jun, Xu Xiaohua, Jin Zhong
National Engineering Research Center of Pesticide, State Key Laboratory of Elementoorganic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resource Chemistry, College of Chemistry and Environmental Sciences, Kashi University, Kashgar 844000, China.
Org Lett. 2024 Jun 7;26(22):4733-4737. doi: 10.1021/acs.orglett.4c01460. Epub 2024 May 23.
For transition-metal-catalyzed C-H functionalization, precise differentiation between remote adjacent C(sp)-H bonds remains a long-standing challenge. Here, the template structure-directivity relationship on remote C-H functionalization of arenes was experimentally and computationally studied. By using geometry-tunable templates, Pd-catalyzed remote - and -C-H activation of benzoic acids was achieved with high site selectivity.
