School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.
School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, 2052, Australia.
Genome Biol. 2024 May 23;25(1):134. doi: 10.1186/s13059-024-03280-0.
The marsupial specific RSX lncRNA is the functional analogue of the eutherian specific XIST, which coordinates X chromosome inactivation. We characterized the RSX interactome in a marsupial representative (the opossum Monodelphis domestica), identifying 135 proteins, of which 54 had orthologues in the XIST interactome. Both interactomes were enriched for biological pathways related to RNA processing, regulation of translation, and epigenetic transcriptional silencing. This represents a remarkable example showcasing the functional coherence of independently evolved lncRNAs in distantly related mammalian lineages.
有袋动物特异性的 RSX lncRNA 是真兽类特异性 XIST 的功能类似物，它协调 X 染色体失活。我们在有袋动物代表（袋貂 Monodelphis domestica）中对 RSX 相互作用组进行了表征，鉴定出 135 种蛋白质，其中 54 种在 XIST 相互作用组中有同源物。这两个相互作用组都富含与 RNA 加工、翻译调控和表观遗传转录沉默相关的生物学途径。这代表了一个显著的例子，展示了在不同的哺乳动物谱系中独立进化的 lncRNA 之间的功能一致性。
