Tsuruta K, Mori N
Nihon Sanka Fujinka Gakkai Zasshi. 1985 Oct;37(10):2023-30.
The high activity of 15-hydroxyprostaglandin dehydrogenase (PGDH) which catalyzes the first step in prostaglandin metabolism has been demonstrated in the human placenta. To investigate the role of placental PGDH (p-PGDH) in the perinatal period, PGDH activity was measured in 167 placentas of gestational ages 37 to 41 weeks. The activity was expressed as n mole/min/non heme protein of 15-keto-PGE2 which was produced by incubation of PGE2 and placental homogenate supernatant. The following data were obtained. p-PGDH activity was significantly lower at the 40 weeks of gestation than at other weeks. There was no difference in placental PGDH activity between cesarean section and vaginal delivery, and between the periods before and after onset labor of cesarean section. p-PGDH activity in the PGs administered group was higher than that in the non PGs group. p-PGDH activity of a male fetus was higher than that of a female. This suggests that p-PGDH activity is under the control of hormones. No relationship was observed between p-PGDH activity and other perinatal factors such as toxemia of pregnancy, parity, Apgar score, birth weight, placental weight, blood loss, and duration of labor.
已证实在人胎盘中，催化前列腺素代谢第一步的15-羟基前列腺素脱氢酶（PGDH）活性很高。为了研究胎盘PGDH（p-PGDH）在围产期的作用，对167例孕龄为37至41周的胎盘进行了PGDH活性测定。活性以PGE2与胎盘匀浆上清液孵育产生的15-酮-PGE2的纳摩尔/分钟/非血红素蛋白表示。获得了以下数据。妊娠40周时的p-PGDH活性显著低于其他孕周。剖宫产与阴道分娩之间，以及剖宫产分娩发动前后的胎盘PGDH活性无差异。给予前列腺素组的p-PGDH活性高于未给予前列腺素组。男胎的p-PGDH活性高于女胎。这表明p-PGDH活性受激素控制。未观察到p-PGDH活性与其他围产期因素之间的关系，如妊娠中毒症、产次、阿氏评分、出生体重、胎盘重量、失血量和产程持续时间。
