Eaves M, Thatcher-Britton K, Rivier J, Vale W, Koob G F
Peptides. 1985 Sep-Oct;6(5):923-6. doi: 10.1016/0196-9781(85)90323-7.
Corticotropin releasing factor (CRF) injected intracerebroventricularly to hypophysectomized and sham hypophysectomized rats produced a dose dependent increase in locomotor activity, but in untreated hypophysectomized rats 10X more CRF was needed to produce a significant increase in activity. Concomitant daily supplements of rat growth hormone, thyroxine, and corticosterone to the hypophysectomized rats eliminated locomotor activity differences between the two groups. There was no statistically significant difference in locomotor response to either saline, 0.1 micrograms CRF, 1.0 micrograms CRF or 10.0 micrograms CRF in the group of animals receiving hormonal supplements. These results demonstrate that CRF can produce behavioral activation in rats independently of its effects on releasing hormones from the pituitary gland.
向垂体切除和假垂体切除的大鼠脑室内注射促肾上腺皮质激素释放因子（CRF）可使运动活性呈剂量依赖性增加，但在未经处理的垂体切除大鼠中，需要10倍剂量的CRF才能使活性显著增加。向垂体切除的大鼠每日补充大鼠生长激素、甲状腺素和皮质酮可消除两组之间的运动活性差异。在接受激素补充的动物组中，对生理盐水、0.1微克CRF、1.0微克CRF或10.0微克CRF的运动反应无统计学显著差异。这些结果表明，CRF可在大鼠中产生行为激活，而与其对垂体释放激素的影响无关。
