人类肠道细菌细胞外囊泡在精神疾病中的新作用及新型药物研发
The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals.
作者信息
Louka Effrosyni, Koumandou Vassiliki Lila
机构信息
Genetics Laboratory, Department of Biotechnology, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.
出版信息
Curr Issues Mol Biol. 2024 May 15;46(5):4751-4767. doi: 10.3390/cimb46050286.
In recent years, further evidence has emerged regarding the involvement of extracellular vesicles in various human physiopathological conditions such as Alzheimer's disease, Parkinson's disease, irritable bowel syndrome, and mental disorders. The biogenesis and cargo of such vesicles may reveal their impact on human health nd disease and set the underpinnings for the development of novel chemical compounds and pharmaceuticals. In this review, we examine the link between bacteria-derived exosomes in the gastrointestinal tract and mental disorders, such as depression and anxiety disorders. Crucially, we focus on whether changes in the gut environment affect the human mental state or the other way around. Furthermore, the possibility of handling bacteria-derived exosomes as vectors of chemicals to treat such conditions is examined.
近年来，关于细胞外囊泡参与多种人类生理病理状况（如阿尔茨海默病、帕金森病、肠易激综合征和精神障碍）的进一步证据已经出现。此类囊泡的生物发生和所载物质可能揭示它们对人类健康和疾病的影响，并为新型化合物和药物的开发奠定基础。在本综述中，我们研究了胃肠道中细菌衍生的外泌体与精神障碍（如抑郁症和焦虑症）之间的联系。至关重要的是，我们关注肠道环境的变化是否会影响人类精神状态，或者反之亦然。此外，还探讨了将细菌衍生的外泌体作为化学物质载体来治疗此类病症的可能性。
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