Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan 215316, China.
Biomolecules. 2024 May 3;14(5):553. doi: 10.3390/biom14050553.
Histone demethylases, enzymes responsible for removing methyl groups from histone proteins, have emerged as critical players in regulating gene expression and chromatin dynamics, thereby influencing various cellular processes. LSD2 and LSD1 have attracted considerable interest among these demethylases because of their associations with cancer. However, while LSD1 has received significant attention, LSD2 has not been recognized to the same extent. In this study, we conduct a comprehensive comparison between LSD2 and LSD1, with a focus on exploring LSD2's implications. While both share structural similarities, LSD2 possesses unique features as well. Functionally, LSD2 shows diverse roles, particularly in cancer, with tissue-dependent roles. Additionally, LSD2 extends beyond histone demethylation, impacting DNA methylation, cancer cell reprogramming, E3 ubiquitin ligase activity and DNA damage repair pathways. This study underscores the distinct roles of LSD2, providing insights into their contributions to cancer and other cellular processes.
组蛋白去甲基酶是负责从组蛋白蛋白上去除甲基基团的酶，已成为调节基因表达和染色质动力学的关键因素，从而影响各种细胞过程。在这些去甲基酶中，LSD2 和 LSD1 由于与癌症有关而引起了相当大的关注。然而，尽管 LSD1 受到了极大的关注，但 LSD2 并没有得到同样的重视。在这项研究中，我们对 LSD2 和 LSD1 进行了全面比较，重点探讨了 LSD2 的意义。虽然它们具有结构相似性，但 LSD2 也具有独特的特征。在功能上，LSD2 显示出多种作用，特别是在癌症中，具有组织依赖性作用。此外，LSD2 不仅仅局限于组蛋白去甲基化，还影响 DNA 甲基化、癌细胞重编程、E3 泛素连接酶活性和 DNA 损伤修复途径。这项研究强调了 LSD2 的独特作用，为它们在癌症和其他细胞过程中的贡献提供了深入的了解。
