Baldino Lucia, Riccardi Domenico, Reverchon Ernesto
Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.
Nanomaterials (Basel). 2024 May 13;14(10):846. doi: 10.3390/nano14100846.
Niosomes are arousing significant interest thanks to their low cost, high biocompatibility, and negligible toxicity. In this work, a supercritical CO-assisted process was performed at 100 bar and 40 °C to produce niosomes at different Span 80/Tween 80 weight ratios. The formulation of cholesterol and 80:20 Span 80/Tween 80 was selected to encapsulate vancomycin, used as a model active compound, to perform a drug release rate comparison between PEGylated and non-PEGylated niosomes. In both cases, nanometric vesicles were obtained, i.e., 214 ± 59 nm and 254 ± 73 nm for non-PEGylated and PEGylated niosomes, respectively, that were characterized by a high drug encapsulation efficiency (95% for non-PEGylated and 98% for PEGylated niosomes). However, only PEGylated niosomes were able to prolong the vancomycin release time up to 20-fold with respect to untreated drug powder, resulting in a powerful strategy to control the drug release rate.
由于其低成本、高生物相容性和可忽略不计的毒性，脂质体引起了广泛关注。在这项工作中，在100巴和40°C的条件下进行了超临界CO辅助过程，以制备不同Span 80/Tween 80重量比的脂质体。选择胆固醇和80:20 Span 80/Tween 80的配方来包裹作为模型活性化合物的万古霉素，以比较聚乙二醇化和非聚乙二醇化脂质体之间的药物释放速率。在这两种情况下，均获得了纳米级囊泡，即非聚乙二醇化脂质体为214±59nm，聚乙二醇化脂质体为254±73nm，其特点是药物包封效率高（非聚乙二醇化脂质体为95%，聚乙二醇化脂质体为98%）。然而，只有聚乙二醇化脂质体能够将万古霉素的释放时间延长至未处理药物粉末的20倍，这是一种控制药物释放速率的有效策略。
