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黄芩根提取物诱导的肝细胞毒性可以通过调节其黄芩苷含量来控制。

Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content.

机构信息

Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba, 278-8510, Japan.

Division of Environmental Chemistry, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-Ku, Kawasaki, Kanagawa, 210-9501, Japan.

出版信息

J Nat Med. 2024 Sep;78(4):978-984. doi: 10.1007/s11418-024-01814-1. Epub 2024 May 24.

DOI:10.1007/s11418-024-01814-1
PMID:38787459
Abstract

Scuellaria Root (SR, root of Scutellaria baicalensis), which has potent anti-inflammatory effects, is a component of useful Kampo formulae. Albeit a low frequency, SR induces serious interstitial pneumonia and liver dysfunction. In this study, to control the adverse effects of SR, we investigated the causal constituent responsible for its hepatocytotoxicity and aimed to develop a method to control it. As a result, we revealed that the hepatocytotoxicity of SR was correlated with its baicalin content, a major constituent in SR. It was confirmed by preparing a baicalin-free SR extract, which exhibited reduced hepatocytotoxicity. The addition of baicalin to the baicalin-free SR extract restored the hepatocytotoxicity, indicating that the hepatocytotoxicity of SR is dependent on its baicalin content. Thus, SR extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content.

摘要

黄芩根（SR，黄芩的根）具有很强的抗炎作用，是一些有用的汉方方剂的组成部分。尽管频率较低，但 SR 会引起严重的间质性肺炎和肝功能障碍。在这项研究中，为了控制 SR 的不良反应，我们研究了导致其肝细胞毒性的原因，并旨在开发一种控制其毒性的方法。结果表明，SR 的肝细胞毒性与其主要成分黄芩苷的含量有关。通过制备不含黄芩苷的 SR 提取物证实了这一点，该提取物显示出降低的肝细胞毒性。向不含黄芩苷的 SR 提取物中添加黄芩苷可恢复其肝细胞毒性，表明 SR 的肝细胞毒性依赖于其黄芩苷含量。因此，通过调节其黄芩苷含量可以控制 SR 提取物诱导的肝细胞毒性。

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本文引用的文献

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Med Hypotheses. 2019 Dec;133:109402. doi: 10.1016/j.mehy.2019.109402. Epub 2019 Sep 19.
2
Quantitative analysis of the anti-inflammatory activity of orengedokuto II: berberine is responsible for the inhibition of NO production.二黄汤抗炎活性的定量分析：小檗碱抑制一氧化氮的产生。
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Synergistic effect of baicalein, wogonin and oroxylin A mixture: multistep inhibition of the NF-κB signalling pathway contributes to an anti-inflammatory effect of Scutellaria root flavonoids.
黄芩素、汉黄芩素和木犀草素混合物的协同作用：对NF-κB信号通路的多步抑制有助于黄芩根黄酮类化合物的抗炎作用。
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In vitro assessment of hepatoprotective agents against damage induced by acetaminophen and CCl.对乙酰氨基酚和四氯化碳诱导损伤的肝保护剂的体外评估
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Baicalin induces apoptosis in hepatic cancer cells in vitro and suppresses tumor growth in vivo.黄芩苷在体外可诱导肝癌细胞凋亡，并在体内抑制肿瘤生长。
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The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation.黄芩苷通过抑制TLR4/NF-κB信号通路激活对实验性结肠炎发挥抗炎作用。
Int Immunopharmacol. 2014 Nov;23(1):294-303. doi: 10.1016/j.intimp.2014.09.005. Epub 2014 Sep 18.
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J Food Sci Technol. 2013 Jun;50(3):615-9. doi: 10.1007/s13197-012-0857-y. Epub 2012 Nov 29.
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J Nat Med. 2013 Apr;67(2):281-8. doi: 10.1007/s11418-012-0679-2. Epub 2012 Jun 23.
9
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