Dinnie Yushra, Everson Frans, Kamau Festus M, Webster Ingrid, Kgokane Boipelo, De Boever Patrick, Goswami Nandu, Strijdom Hans
Centre for Cardio-metabolic Research in Africa, Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Centre for Cardio-metabolic Research in Africa, Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa . Email:
Cardiovasc J Afr. 2024 Apr 5;34:1-9. doi: 10.5830/CVJA-2024-005.
Cardiovascular risk is a health concern in people living with HIV/AIDS (PLWH). This longitudinal study (baseline vs 36 months) aimed to investigate the relationship between body composition and markers of cardiovascular risk in a South African study population [HIV free, = 22 vs HIV positive on antiretroviral therapy (HIV+ART), = 73)]. Health questionnaires, anthropometric measurements, biochemical analyses and flow-mediated dilation were performed. Linear mixed-model statistical analyses were applied. The HIV+ART vs the HIV-free groups were independently associated with body mass index (BMI) [-4.92 (-7.99 to -1.84), = 0.002] and waist circumference [-10.5 (-17.2 to -3.77), = 0.003]. ART duration was associated with BMI [2.60 (0.57-4.62), = 0.013], waist circumference [3.83 (0.03-7.63), = 0.048] and high-density lipoprotein cholesterol [20.18 (2.37-41.09), = 0.025]. The data showed that intricate relationships existed in this study population between HIV, ART, body composition and cardiometabolic variables. There is a need for more research investigating cardiovascular risk in PLWH, particularly in the context of changes in body composition measures.
心血管风险是艾滋病毒/艾滋病感染者（PLWH）的一个健康问题。这项纵向研究（基线对比36个月）旨在调查南非研究人群[未感染艾滋病毒，n = 22；接受抗逆转录病毒治疗的艾滋病毒阳性者（HIV+ART），n = 73]的身体组成与心血管风险标志物之间的关系。进行了健康问卷调查、人体测量、生化分析和血流介导的血管舒张测定。应用了线性混合模型统计分析。HIV+ART组与未感染艾滋病毒组分别独立地与体重指数（BMI）[-4.92（-7.99至-1.84），P = 0.002]和腰围[-10.5（-17.2至-3.77），P = 0.003]相关。抗逆转录病毒治疗持续时间与BMI[2.60（0.57 - 4.62），P = 0.013]、腰围[3.83（0.03 - 7.63），P = 0.048]和高密度脂蛋白胆固醇[20.18（2.37 - 41.09），P = 0.025]相关。数据表明，在该研究人群中，艾滋病毒、抗逆转录病毒治疗、身体组成和心脏代谢变量之间存在复杂的关系。有必要开展更多研究来调查PLWH的心血管风险，特别是在身体组成指标变化的背景下。
