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肥胖治疗的一场革命

A Revolution in the Treatment of Obesity.

作者信息

Spector Reynold

机构信息

Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, NJ.

出版信息

Am J Med. 2024 Oct;137(10):925-928. doi: 10.1016/j.amjmed.2024.05.023. Epub 2024 May 22.

DOI:10.1016/j.amjmed.2024.05.023
PMID:38788825
Abstract

Forty percent of Americans are obese and 20% are overweight. Until recently, notwithstanding great efforts to combat this chronic, worsening epidemic, the only therapy that "worked" was surgery. However, recently, a new class of safe drugs (incretins) have been developed that cause obese patients to lose ∼20 to 25% of their body weight. Herein we recount this revolution and its implications.

摘要

40%的美国人肥胖,20%超重。直到最近,尽管为对抗这一慢性且日益严重的流行病付出了巨大努力,但唯一“有效的”疗法是手术。然而,最近研发出了一类新型安全药物(肠促胰岛素),能使肥胖患者减轻约20%至25%的体重。在此我们讲述这一变革及其影响。

相似文献

1
A Revolution in the Treatment of Obesity.肥胖治疗的一场革命
Am J Med. 2024 Oct;137(10):925-928. doi: 10.1016/j.amjmed.2024.05.023. Epub 2024 May 22.
2
Curbing the Obesity Epidemic: Should GLP-1 Receptor Agonists Be the Standard of Care for Obesity?遏制肥胖流行:GLP-1 受体激动剂是否应该成为肥胖治疗的标准?
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Incretin hormone agonists: Current and emerging pharmacotherapy for obesity management.肠促胰岛素激素激动剂:肥胖管理的当前及新兴药物治疗方法。
Pharmacotherapy. 2024 Sep;44(9):738-752. doi: 10.1002/phar.4607. Epub 2024 Sep 3.
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Treatment of obesity: will incretin agonists make bariatric surgery a thing of the past?肥胖症的治疗:肠促胰岛素激动剂会使减肥手术成为历史吗?
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Therapeutic advances in obesity management: an overview of the therapeutic interventions.肥胖管理治疗进展:治疗干预概述。
Front Endocrinol (Lausanne). 2024 Apr 23;15:1364503. doi: 10.3389/fendo.2024.1364503. eCollection 2024.
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Why does GLP-1 agonist combined with GIP and/or GCG agonist have greater weight loss effect than GLP-1 agonist alone in obese adults without type 2 diabetes?为何在无2型糖尿病的肥胖成年人中,胰高糖素样肽-1(GLP-1)激动剂联合葡萄糖依赖性促胰岛素多肽(GIP)和/或胰高血糖素原(GCG)激动剂比单独使用GLP-1激动剂具有更强的减重效果?
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Potent incretin-based therapy for obesity: A systematic review and meta-analysis of the efficacy of semaglutide and tirzepatide on body weight and waist circumference, and safety.基于肠促胰岛素的强效肥胖治疗:司美格鲁肽和替尔泊肽对体重和腰围影响及安全性的系统评价与荟萃分析
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A Review of Incretin Therapies Approved and in Late-Stage Development for Overweight and Obesity Management.《用于超重和肥胖管理的在研及已获批的肠促胰岛素治疗药物的综述》。
Endocr Pract. 2024 Mar;30(3):292-303. doi: 10.1016/j.eprac.2023.12.010. Epub 2023 Dec 18.
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[Incretins as the basis of obesity treatment].[以肠促胰岛素为基础的肥胖症治疗]
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Dual GIP/GLP-1 receptor agonists: New advances for treating type-2 diabetes.双重 GIP/GLP-1 受体激动剂:治疗 2 型糖尿病的新进展。
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引用本文的文献

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Gut-to-brain regulation of aging through neuropeptide F, insulin, and juvenile hormone.通过神经肽 F、胰岛素和保幼激素实现衰老的肠脑调控。
Proc Natl Acad Sci U S A. 2024 Oct 22;121(43):e2411987121. doi: 10.1073/pnas.2411987121. Epub 2024 Oct 16.
2
Gut-to-brain regulation of aging through neuropeptide F, insulin and juvenile hormone.通过神经肽F、胰岛素和保幼激素实现肠道对大脑衰老的调节。
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