Yang Mingjie, Yang Xinke, Li Jingtao, Wei Hailiang, Yan Shuguang
Department of Gastroenterology, College of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Department of Infectious Diseases, Affiliated Hospital, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024 May;40(5):455-459.
Ulcerative colitis (UC) is an autoimmune disease based on the persistent damage of colonic mucosal barrier. It has been found that the abnormal expression of follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells is closely related to the occurrence and development of UC. Tfh cells can secrete pro-inflammatory factors and assist B cells to produce antibodies, which can promote the development of UC, while Tfr cells can inhibit the activity of Tfh cells and secrete anti-inflammatory factors. How to regulate the balance between them has become one of the potential therapeutic targets of UC. Vasoactive intestinal peptide (VIP) has preventive and therapeutic effect on UC, and its mechanism is closely related to the regulation of Tfh/Tfr cell balance, which can provide help for the treatment of UC.
溃疡性结肠炎（UC）是一种基于结肠黏膜屏障持续受损的自身免疫性疾病。研究发现，滤泡辅助性T（Tfh）细胞和滤泡调节性T（Tfr）细胞的异常表达与UC的发生发展密切相关。Tfh细胞可分泌促炎因子并辅助B细胞产生抗体，从而促进UC的发展，而Tfr细胞可抑制Tfh细胞的活性并分泌抗炎因子。如何调节它们之间的平衡已成为UC潜在的治疗靶点之一。血管活性肠肽（VIP）对UC具有预防和治疗作用，其机制与Tfh/Tfr细胞平衡的调节密切相关，可为UC的治疗提供帮助。
