Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Genes (Basel). 2024 Apr 25;15(5):538. doi: 10.3390/genes15050538.
Colorectal cancer (CRC) accounts for about 10% of all cancer cases and 9% of cancer-related deaths globally. In the United States alone, CRC represents approximately 12.6% of all cancer cases, with a mortality rate of about 8%. CRC is now the first leading cause of cancer death in men younger than age 50 and second in women younger than age 50. This review delves into the genetic landscape of CRC, highlighting key mutations and their implications in disease progression and treatment. We provide an overview of the current and emerging therapeutic strategies tailored to individual genomic profiles.
结直肠癌（CRC）约占全球所有癌症病例的 10%和癌症相关死亡的 9%。仅在美国，CRC 约占所有癌症病例的 12.6%，死亡率约为 8%。CRC 现在是 50 岁以下男性癌症死亡的首要原因，在 50 岁以下女性中排名第二。本综述深入探讨了结直肠癌的遗传图谱，强调了关键突变及其对疾病进展和治疗的影响。我们概述了针对个体基因组图谱的当前和新兴治疗策略。
