Neurology Asklepios Klinik Barmbek, Rübenkamp 220, 22307 Hamburg, Germany.
Institute of Neuropathology, Philipps-University Marburg, 35037 Marburg, Germany.
Genes (Basel). 2024 May 14;15(5):620. doi: 10.3390/genes15050620.
Transposable elements (TEs) are characterized by their ability to change their genomic position. Through insertion or recombination leading to deletions and other chromosomal aberrations, they can cause genetic instability. The extent to which they thereby exert regulatory influence on cellular functions is unclear. To better characterize TEs in processes such as carcinogenesis, we used the well-established Xiphophorus melanoma model. By transcriptome sequencing, we show that an increasing total number in transposons correlates with progression of malignancy in melanoma samples from Xiphophorus interspecific hybrids. Further, by comparing the presence of TEs in the parental genomes of and , we could show that even in closely related species, genomic location and spectrum of TEs are considerably different.
转座元件 (TEs) 的特征是它们能够改变其基因组位置。通过插入或重组导致缺失和其他染色体异常，它们可以引起遗传不稳定性。它们在多大程度上对细胞功能施加调节影响尚不清楚。为了更好地描述在癌变等过程中的转座元件，我们使用了成熟的 Xiphophorus 黑色素瘤模型。通过转录组测序，我们表明转座元件的总数增加与 Xiphophorus 种间杂种黑色素瘤样本恶性程度的进展相关。此外，通过比较 和 亲本组中的 TE 存在情况，我们可以表明，即使在密切相关的物种中，TE 的基因组位置和谱也有很大的不同。
