Corrales J J, Pastor I, García L C, Gonzalez J M, Montero J, De Castro S, Miralles J M
Urol Int. 1985;40(6):307-13. doi: 10.1159/000281119.
The content of cytoplasmic androgen receptors (Bmax) was analyzed in non-tumoral renal tissue of 12 men and 15 postmenopausal women using a synthetic androgen (methyltrienolone) as ligand and a method of dextran-coated charcoal. The Bmax in both sexes was compared, establishing correlations between it and circulating levels of testosterone, dehydroepiandrosterone sulfate, androstenedione, and estradiol to find out the possible influence of the hormonal environment on androgen receptors in the human kidney. No differences in Bmax were observed between males (46.3 +/- 24 fmol/g of tissue) and females (45.4 +/- 26 fmol/g), in spite of the significantly greater (p less than 0.01) levels of circulating testosterone in the former group. No significant linear correlations existed between any of the steroids analyzed and the Bmax. These results demonstrate the existence of androgenic receptors in non-tumoral human kidney and indicate that its content is not regulated by circulating levels of testosterone. The concentrations of the principal extratesticular androgens and estradiol do not seem to have a quantitative influence on these androphilic proteins either.
使用合成雄激素（甲基三烯olone）作为配体，采用葡聚糖包被活性炭法，对12名男性和15名绝经后女性的非肿瘤性肾组织中的细胞质雄激素受体含量（Bmax）进行了分析。比较了两性的Bmax，并建立了其与睾酮、硫酸脱氢表雄酮、雄烯二酮和雌二醇循环水平之间的相关性，以探究激素环境对人肾雄激素受体的可能影响。尽管男性组的循环睾酮水平显著更高（p<0.01），但男性（46.3±24 fmol/g组织）和女性（45.4±26 fmol/g）的Bmax未观察到差异。所分析的任何一种类固醇与Bmax之间均无显著线性相关性。这些结果证明了非肿瘤性人肾中存在雄激素受体，并表明其含量不受循环睾酮水平的调节。主要的睾丸外雄激素和雌二醇的浓度似乎也对这些亲雄激素蛋白没有定量影响。
