Ferrán Sol, Rodríguez-Zanetti Carla, Garaycochea Octavio, Terrasa David, Prieto-Matos Carlos, Del Río Beatriz, Alzuguren Maria Pilar, Fernández Secundino
Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Medical Engineering Laboratory, School of Medicine, Universidad de Navarra, 31008 Pamplona, Spain.
Bioengineering (Basel). 2024 May 10;11(5):475. doi: 10.3390/bioengineering11050475.
(1) Background: Assessing phonatory disorders due to laryngeal biomechanical alterations requires aerodynamic analysis, assessing subglottic pressure, transglottic flow, and laryngeal resistance. This study explores whether the acoustic parameter, the relative fundamental frequency (RFF), can be studied using the current acoustic analysis protocol at the University of Navarra's voice laboratory and its association with pathologies linked to laryngeal biomechanical alterations. (2) Methods: A retrospective cohort study included patients diagnosed with muscular tension dysphonia, organic lesions of the vocal fold, and vocal fold paralysis (VFP) at the Clínica Universidad de Navarra from 2019 to 2021. Each patient underwent endoscopic laryngeal exploration, followed by acoustic study, RFF calculation, and an aerodynamic study. Additionally, a control group was recruited. (3) Results: 79 patients and 22 controls were studied. Two-way ANOVA showed significant effects for groups and cycles in offset and onset cycles. Statistically significant differences were observed in cycle 1 onset among all groups and in cycles 1 and 2 between the control group and non-healthy groups. (4) Conclusions: RFF is a valuable indicator of phonatory biomechanics, distinguishing healthy and pathological voices and different disorders. RFF in onset cycles offers a cost-effective, accurate method for assessing biomechanical disorders without complex aerodynamic analyses. This study describes RFF values in VFP for the first time, revealing differences regardless of aerodynamic patterns.
(1) 背景:评估因喉部生物力学改变引起的发声障碍需要进行空气动力学分析,评估声门下压力、声门跨声门气流和喉部阻力。本研究探讨声学参数相对基频(RFF)是否可以通过纳瓦拉大学嗓音实验室当前的声学分析方案进行研究,以及它与喉部生物力学改变相关疾病的关联。(2) 方法:一项回顾性队列研究纳入了2019年至2021年在纳瓦拉大学临床医院被诊断为肌肉紧张性发声障碍、声带器质性病变和声带麻痹(VFP)的患者。每位患者均接受了喉镜检查,随后进行声学研究、RFF计算和空气动力学研究。此外,还招募了一个对照组。(3) 结果:共研究了79例患者和22名对照。双向方差分析显示,在偏移和起始周期中,组间和周期间存在显著影响。在所有组的第1周期起始以及对照组与非健康组之间的第1和第2周期中观察到统计学上的显著差异。(4) 结论:RFF是发声生物力学的一个有价值指标,可区分健康和病理性嗓音以及不同的疾病。起始周期中的RFF为评估生物力学障碍提供了一种经济有效、准确的方法,无需复杂的空气动力学分析。本研究首次描述了VFP中的RFF值,揭示了无论空气动力学模式如何均存在差异。