Li Aohan, Wu Siyuan, Li Qian, Wang Qianqian, Chen Yingqing
Chronic Disease Research Center, Medical College, Dalian University, Dalian 116622, China.
Engineering Technology Research Center for The Utilization of Functional Components of Organic Natural Products, Dalian University, Dalian 116622, China.
Antioxidants (Basel). 2024 Apr 25;13(5):515. doi: 10.3390/antiox13050515.
Fibrosis, a pathological alteration of the repair response, involves continuous organ damage, scar formation, and eventual functional failure in various chronic inflammatory disorders. Unfortunately, clinical practice offers limited treatment strategies, leading to high mortality rates in chronic diseases. As part of investigations into gaseous mediators, or gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (HS), numerous studies have confirmed their beneficial roles in attenuating fibrosis. Their therapeutic mechanisms, which involve inhibiting oxidative stress, inflammation, apoptosis, and proliferation, have been increasingly elucidated. Additionally, novel gasotransmitters like hydrogen (H) and sulfur dioxide (SO) have emerged as promising options for fibrosis treatment. In this review, we primarily demonstrate and summarize the protective and therapeutic effects of gaseous mediators in the process of fibrosis, with a focus on elucidating the underlying molecular mechanisms involved in combating fibrosis.
纤维化是修复反应的一种病理改变，涉及多种慢性炎症性疾病中的持续性器官损伤、瘢痕形成以及最终的功能衰竭。不幸的是，临床实践中的治疗策略有限，导致慢性病死亡率很高。作为对包括一氧化氮（NO）、一氧化碳（CO）和硫化氢（HS）等气态介质或气体信号分子研究的一部分，大量研究证实了它们在减轻纤维化方面的有益作用。它们的治疗机制，包括抑制氧化应激、炎症、细胞凋亡和增殖，已得到越来越多的阐明。此外，像氢气（H）和二氧化硫（SO）等新型气体信号分子已成为纤维化治疗的有前景的选择。在这篇综述中，我们主要展示并总结气态介质在纤维化过程中的保护和治疗作用，重点是阐明对抗纤维化所涉及的潜在分子机制。
