School of Biosciences, University of Nottingham, Loughborough LE12 5RD, UK; School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau.
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.
Trends Pharmacol Sci. 2018 Jul;39(7):624-634. doi: 10.1016/j.tips.2018.03.009. Epub 2018 Apr 26.
Garlic (Allium sativum) and allied plant species are rich sources of sulfur compounds. Major roles for garlic and its sulfur constituents include the regulation of vascular homeostasis and the control of metabolic systems linked to nutrient metabolism. Recent studies have indicated that some of these sulfur compounds, such as diallyl trisulfide (DATS), alter the levels of gaseous signalling molecules including nitric oxide (NO), hydrogen sulfide (HS), and perhaps carbon monoxide (CO) in mammalian tissues. These gases are important in cellular processes associated with the cardiovascular system, inflammation, and neurological functions. Importantly, these studies build on the known biological effects of garlic and associated sulfur constituents. This review highlights our current understanding of the health benefits attributed to edible plants like garlic.
大蒜（Allium sativum）和相关植物物种是硫化合物的丰富来源。大蒜及其硫成分的主要作用包括调节血管内稳态和控制与营养代谢相关的代谢系统。最近的研究表明，这些硫化合物中的一些，如二烯丙基三硫化物（DATS），会改变包括一氧化氮（NO）、硫化氢（HS）甚至一氧化碳（CO）在内的气态信号分子在哺乳动物组织中的水平。这些气体在与心血管系统、炎症和神经功能相关的细胞过程中很重要。重要的是，这些研究建立在已知的大蒜及其相关硫成分的生物学效应的基础上。本文综述了我们目前对大蒜等可食用植物的健康益处的认识。
