Lindenberg S, Steentoft P, Sørensen S S, Olesen H P
Acta Chir Scand. 1985;151(6):525-7.
The preventive effect of fibrin sealant on post-operative formation of peritoneal adhesions was investigated in rats. Intraperitoneal adhesion formation was induced with a standardized, sutured defect in the peritoneum. The influence of sealant thickness and lifetime was evaluated by application of a thin and a thick layer of fibrin sealant containing high or low concentration of antiplasmin. Assessment of adhesion formation one week post-operatively showed significantly less adhesion to the defects covered with the thick layer of sealant having high or low antiplasmin concentration as compared with defects having only a thin sealant layer or control rats without sealant.
在大鼠中研究了纤维蛋白密封剂对术后腹膜粘连形成的预防作用。通过在腹膜上制造标准化的缝合缺损来诱导腹腔粘连形成。通过应用含有高浓度或低浓度抗纤溶酶的薄或厚纤维蛋白密封剂层来评估密封剂厚度和寿命的影响。术后一周对粘连形成的评估显示，与仅具有薄密封剂层的缺损或没有密封剂的对照大鼠相比，覆盖有高或低抗纤溶酶浓度厚密封剂层的缺损处粘连明显减少。
