Weldetsadik Ermias Tamiru, Li Na, Li Jingjuan, Shang Jiahuan, Zhu Hongtao, Zhang Yingjun
State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Foods. 2024 May 11;13(10):1495. doi: 10.3390/foods13101495.
The fruit of (Anacardiaceae), known as south wild jujube in China, has been consumed widely in several regions of the world to produce fruit pastille and leathers, juice, jam, and candy. A comprehensive chemical study on the fresh fruits led to the isolation and identification of 18 compounds, including 7 new (-) and 11 known (-) comprised of 5 alkenyl (cyclohexenols and cyclohexenones) derivatives (-), 3 benzofuran derivatives (-), 6 flavonoids (-) and 4 lignans (-). Their structures were elucidated by extensive spectroscopic analysis. The known lignans - were isolated from the genus for the first time. Most of the isolates exhibited significant inhibitory activity on -glucosidase with IC values from 2.26 ± 0.06 to 43.9 ± 0.96 μM. Molecular docking experiments strongly supported the potent -glucosidase inhibitory activity. The results indicated that fruits could be an excellent source of functional foods that acquire potential hypoglycemic bioactive components.
漆树科（Anacardiaceae）[植物]的果实，在中国被称为南酸枣，在世界上几个地区已被广泛用于制作果脯、果汁、果酱和糖果。对其新鲜果实进行的全面化学研究导致分离并鉴定出18种化合物，包括7种新的（-）和11种已知的（-）化合物，由5种烯基（环己烯醇和环己烯酮）衍生物（-）、3种苯并呋喃衍生物（-）、6种黄酮类化合物（-）和4种木脂素（-）组成。通过广泛的光谱分析阐明了它们的结构。已知的木脂素 - 首次从该属中分离出来。大多数分离物对α - 葡萄糖苷酶表现出显著的抑制活性，IC值为2.26±0.06至43.9±0.96μM。分子对接实验有力地支持了其对α - 葡萄糖苷酶的强效抑制活性。结果表明，[该植物]果实可能是获取具有潜在降血糖生物活性成分的功能性食品的优质来源。
