Department of Natural Sciences, The Open University of Israel, Ra'anana 4353701, Israel.
Int J Mol Sci. 2024 May 13;25(10):5295. doi: 10.3390/ijms25105295.
Some signaling processes mediated by G protein-coupled receptors (GPCRs) are modulated by membrane potential. In recent years, increasing evidence that GPCRs are intrinsically voltage-dependent has accumulated. A recent publication challenged the view that voltage sensors are embedded in muscarinic receptors. Herein, we briefly discuss the evidence that supports the notion that GPCRs themselves are voltage-sensitive proteins and an alternative mechanism that suggests that voltage-gated sodium channels are the voltage-sensing molecules involved in such processes.
一些由 G 蛋白偶联受体（GPCR）介导的信号转导过程受膜电位调节。近年来，越来越多的证据表明 GPCR 具有内在的电压依赖性。最近的一篇出版物对电压感受器嵌入毒蕈碱受体的观点提出了挑战。在此，我们简要讨论支持 GPCR 本身是电压敏感蛋白这一观点的证据，以及另一种观点，即认为电压门控钠通道是涉及这些过程的电压感应分子。
