Garcês Andreia, Pires Isabel, Garcês Sara
Exotic and Wildlife Service, Veterinary Hospital University of Trás-os-Montes and Alto Douro, Quinta dos Prados, 4500-801 Vila Real, Portugal.
CECAV, Centre for Animal Sciences and Veterinary Studies, Associate Laboratory for Animal and Veterinary Science-AL4AnimalS, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal.
Animals (Basel). 2024 May 15;14(10):1474. doi: 10.3390/ani14101474.
Paleo-oncology studies neoplastic diseases in fossilised animals, including human remains. Recent advancements have enabled more accurate diagnoses of ancient pathologies despite the inherent challenges in identifying tumours in fossils-such as the rarity of well-preserved specimens, the predominance of bone remains, and the difficulty in distinguishing neoplastic from non-neoplastic lesions. This study compiles reports of tumours in fossilised animals, highlighting that neoplasms are present in a wide range of vertebrates and drawing comparisons to modern instances of similar diseases. The findings underscore the multifactorial aetiology of tumours, which involves genetic, environmental, and lifestyle factors, and suggest that tumours have been around for at least 350 million years.
古肿瘤学研究化石动物（包括人类遗骸）中的肿瘤性疾病。尽管在化石中识别肿瘤存在固有挑战，如保存完好的标本稀少、骨骼遗骸占主导以及难以区分肿瘤性病变和非肿瘤性病变，但最近的进展已使对古代病理学的诊断更加准确。本研究汇编了化石动物肿瘤的报告，强调肿瘤存在于广泛的脊椎动物中，并与现代类似疾病实例进行了比较。研究结果强调了肿瘤的多因素病因，涉及遗传、环境和生活方式因素，并表明肿瘤至少已经存在了3.5亿年。
