Varoquaux O, Trawale J M, Doll J, Andrieu J, Grosbuis S, Pays M, Advenier C
Br J Clin Pharmacol. 1985 Dec;20(6):699-702. doi: 10.1111/j.1365-2125.1985.tb05133.x.
A pharmacokinetic study of ranitidine was performed in 14 patients with haematemesis divided into two groups according to the severity of blood loss. Pharmacokinetic values were calculated from plasma concentrations after the first of three daily injections (100 mg) and compared with those obtained in five healthy volunteers (50 mg i.v.). There were no significant differences between patients in the two haemorrhage groups and controls. The low, or even questionable, effectiveness of histamine H2-receptor antagonists in the treatment of upper gastrointestinal haemorrhage does not seem to be due to pharmacokinetic factors.
对14例呕血患者进行了雷尼替丁的药代动力学研究，根据失血量的严重程度将患者分为两组。药代动力学值是在每日三次注射（100毫克）中的首次注射后，根据血浆浓度计算得出的，并与5名健康志愿者静脉注射50毫克后获得的值进行比较。两个出血组的患者与对照组之间没有显著差异。组胺H2受体拮抗剂在上消化道出血治疗中疗效低甚至存疑，这似乎并非由药代动力学因素所致。
