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前列腺癌治疗中的辐射安全评估：I-125 近距离放射治疗的预测方法

Radiation Safety Assessment in Prostate Cancer Treatment: A Predictive Approach for I-125 Brachytherapy.

作者信息

Chuang Ho-Da, Lin Yu-Hung, Lin Chin-Hsiung, Lai Yuan-Chun, Wu Chin-Hui, Hsu Shih-Ming

机构信息

Medical Physics and Radiation Measurements Laboratory, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.

Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.

出版信息

Cancers (Basel). 2024 May 7;16(10):1790. doi: 10.3390/cancers16101790.

DOI:10.3390/cancers16101790
PMID:38791869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11120066/
Abstract

This study uses Monte Carlo simulation and experimental measurements to develop a predictive model for estimating the external dose rate associated with permanent radioactive source implantation in prostate cancer patients. The objective is to estimate the accuracy of the patient's external dose rate measurement. First, I-125 radioactive sources were implanted into Mylar window water phantoms to simulate the permanent implantation of these sources in patients. Water phantom experimental measurement was combined with Monte Carlo simulation to develop predictive equations, whose performance was verified against external clinical data. The model's accuracy in predicting the external dose rate in patients with permanently implanted I-125 radioactive sources was high (R = 0.999). A comparative analysis of the experimental measurements and the Monte Carlo simulations revealed that the maximum discrepancy between the measured and calculated values for the water phantom was less than 5.00%. The model is practical for radiation safety assessments, enabling the evaluation of radiation exposure risks to individuals around patients with permanently implanted I-125 radioactive sources.

摘要

本研究采用蒙特卡罗模拟和实验测量方法，建立了一个预测模型，用于估算前列腺癌患者永久性放射性源植入后的外照射剂量率。目的是评估患者外照射剂量率测量的准确性。首先，将I-125放射性源植入聚酯薄膜窗口水模体中，以模拟这些源在患者体内的永久性植入。将水模体实验测量与蒙特卡罗模拟相结合，建立预测方程，并根据外部临床数据验证其性能。该模型在预测永久性植入I-125放射性源患者的外照射剂量率方面具有较高的准确性（R = 0.999）。实验测量与蒙特卡罗模拟的对比分析表明，水模体测量值与计算值之间的最大差异小于5.00%。该模型对于辐射安全评估具有实用性，能够评估永久性植入I-125放射性源患者周围个体的辐射暴露风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f02/11120066/292064ad3e9f/cancers-16-01790-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f02/11120066/4df3ae98ad52/cancers-16-01790-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f02/11120066/f88fa9ba7a62/cancers-16-01790-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f02/11120066/2bb021e8fff2/cancers-16-01790-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f02/11120066/292064ad3e9f/cancers-16-01790-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f02/11120066/4df3ae98ad52/cancers-16-01790-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f02/11120066/f88fa9ba7a62/cancers-16-01790-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f02/11120066/2bb021e8fff2/cancers-16-01790-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f02/11120066/292064ad3e9f/cancers-16-01790-g004.jpg

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本文引用的文献

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J Natl Compr Canc Netw. 2023 Oct;21(10):1067-1096. doi: 10.6004/jnccn.2023.0050.
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Determination of a reliable assessment for occupational eye lens dose in nuclear medicine.确定核医学职业性眼晶状体剂量的可靠评估方法。
J Appl Clin Med Phys. 2022 Aug;23(8):e13713. doi: 10.1002/acm2.13713. Epub 2022 Jul 1.
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GEC-ESTRO ACROP prostate brachytherapy guidelines.GEC-ESTRO ACROP 前列腺近距离治疗指南。
Radiother Oncol. 2022 Feb;167:244-251. doi: 10.1016/j.radonc.2021.12.047. Epub 2022 Jan 6.
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An artificial neural network based approach for estimating the density of liquid applied in gamma transmission and gamma scattering techniques.基于人工神经网络的方法，用于估计伽马透射和伽马散射技术中应用的液体密度。
Appl Radiat Isot. 2021 Mar;169:109570. doi: 10.1016/j.apradiso.2020.109570. Epub 2020 Dec 24.
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ICRP Publication 119: Compendium of dose coefficients based on ICRP Publication 60.国际放射防护委员会第119号出版物：基于国际放射防护委员会第60号出版物的剂量系数汇编。
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