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肾栓塞与心房黏液瘤相关:病例报告及文献复习。

Renal Embolism Associated with the Atrial Myxoma: A Case Report and Literature Review.

机构信息

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ami 300-0395, Ibaraki, Japan.

Department of Cardiology, Tokyo Medical University Ibaraki Medical Center, Ami 300-0395, Ibaraki, Japan.

出版信息

Medicina (Kaunas). 2024 Apr 24;60(5):694. doi: 10.3390/medicina60050694.

Abstract

Renal embolisms due to cardiac myxomas are extremely rare; the clinical course, treatment, and prognosis of this disease are not established. A 69-year-old Japanese woman who underwent a nephrectomy for renal cell carcinoma 3 years earlier was hospitalized with a right occipital lobe cerebral infarction. Her renal function suddenly worsened 3 days post-admission: her serum creatinine rose from 1.46 mg/dL to 6.57 mg/dL and then to 8.03 mg/dL the next day, and hemodialysis therapy was started. Abdominal computed tomography (CT) scans showed patchy non-contrasted low-density areas in the right kidney, and chest CT scans and transesophageal ultrasonography revealed a left atrial tumor. We diagnosed renal infarction due to a left atrial myxoma. Hemodialysis and anticoagulant therapy (heparin) were continued, followed by the cardiac myxoma's resection. The patient's renal function gradually improved post-surgery, and the hemodialysis was discontinued. Considering our patient and 19 other case reports of renal infarction associated with cardiac myxoma, the treatment for such a renal infarction and the outcomes differ depending on the embolus site. The poor outcome of abdominal aortic embolism requires a prompt embolectomy, whereas a branch renal artery embolism requires anticoagulation therapy to prevent thrombosis formation around the myxoma.

摘要

心脏黏液瘤导致的肾栓塞极为罕见;该病的临床病程、治疗和预后尚未明确。一位 69 岁日本女性,3 年前因肾细胞癌接受了肾切除术,因右侧枕叶脑梗死入院。她的肾功能在入院后 3 天突然恶化:血清肌酐从 1.46mg/dL 上升至 6.57mg/dL,次日又上升至 8.03mg/dL,开始进行血液透析治疗。腹部 CT 扫描显示右肾有斑片状非对比低密度区,胸部 CT 扫描和经食管超声心动图显示左心房有肿瘤。我们诊断为左心房黏液瘤导致的肾梗死。继续进行血液透析和抗凝治疗(肝素),随后切除心脏黏液瘤。术后患者的肾功能逐渐改善,停止了血液透析。考虑到我们的患者和其他 19 例与心脏黏液瘤相关的肾梗死病例报告,这种肾梗死的治疗和结果因栓子部位而异。腹主动脉栓塞的不良预后需要及时进行取栓术,而分支肾动脉栓塞则需要抗凝治疗以防止黏液瘤周围血栓形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/333c/11123329/545c0b5d8fdb/medicina-60-00694-g001.jpg

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