Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Clinic of Infectious Diseases, University of Bari "Aldo Moro", Piazza Giulio Cesare n. 11 Cap, 70124 Bari, Italy.
Independent Statistician, 36020 Solagna, Italy.
Viruses. 2024 Apr 26;16(5):688. doi: 10.3390/v16050688.
Coronavirus disease 2019 (COVID-19) can lead to persistent and debilitating symptoms referred to as Post-Acute sequelae of SARS-CoV-2 infection (PASC) This broad symptomatology lasts for months after the acute infection and impacts physical and mental health and everyday functioning. In the present study, we aimed to evaluate the prevalence and predictors of long-term impairment of working ability in non-elderly people hospitalised for COVID-19. This cross-sectional study involved 322 subjects hospitalised for COVID-19 from 1 March 2020 to 31 December 2022 in the University Hospital of Bari, Apulia, Italy, enrolled at the time of their hospital discharge and followed-up at a median of 731 days since hospitalization (IQR 466-884). Subjects reporting comparable working ability and those reporting impaired working ability were compared using the Mann-Whitney test (continuous data) and Fisher's test or Chi-Square test (categorical data). Multivariable analysis of impaired working ability was performed using a logistic regression model. Among the 322 subjects who were interviewed, 184 reported comparable working ability (57.1%) and 134 reported impaired working ability (41.6%) compared to the pre-COVID-19 period. Multivariable analysis identified age at hospital admission (OR 1.02, 95% CI 0.99 to 1.04), female sex (OR 1.90, 95% CI 1.18 to 3.08), diabetes (OR 3.73, 95% CI 1.57 to 9.65), receiving oxygen during hospital stay (OR 1.76, 95% CI 1.01 to 3.06), and severe disease (OR 0.51, 95% CI 0.26 to 1.01) as independent predictors of long-term impaired working ability after being hospitalised for COVID-19. Our findings suggest that PASC promotes conditions that could result in decreased working ability and unemployment. These results highlight the significant impact of this syndrome on public health and the global economy, and the need to develop clinical pathways and guidelines for long-term care with specific focus on working impairment.
2019 年冠状病毒病（COVID-19）可导致被称为 SARS-CoV-2 感染后急性后遗症（PASC）的持续和衰弱症状。这种广泛的症状在急性感染后持续数月，影响身心健康和日常功能。在本研究中，我们旨在评估因 COVID-19 住院的非老年人群长期工作能力受损的患病率和预测因素。这项横断面研究涉及 2020 年 3 月 1 日至 2022 年 12 月 31 日期间在意大利普利亚大区巴里大学医院住院的 322 名因 COVID-19 住院的患者，在出院时进行了入组，并在住院后中位数 731 天（IQR 466-884）进行了随访。使用 Mann-Whitney 检验（连续数据）和 Fisher 检验或 Chi-Square 检验（分类数据）比较报告工作能力相当和报告工作能力受损的患者。使用逻辑回归模型对工作能力受损进行多变量分析。在接受访谈的 322 名患者中，与 COVID-19 前相比，184 名患者报告工作能力相当（57.1%），134 名患者报告工作能力受损（41.6%）。多变量分析确定住院时的年龄（OR 1.02，95%CI 0.99 至 1.04）、女性（OR 1.90，95%CI 1.18 至 3.08）、糖尿病（OR 3.73，95%CI 1.57 至 9.65）、住院期间吸氧（OR 1.76，95%CI 1.01 至 3.06）和严重疾病（OR 0.51，95%CI 0.26 至 1.01）是 COVID-19 住院后长期工作能力受损的独立预测因素。我们的研究结果表明，PASC 可导致工作能力下降和失业等情况。这些结果突出表明，该综合征对公共卫生和全球经济具有重大影响，需要制定临床路径和指南，为工作受损的患者提供长期护理。
Zotero 插件