Mellem H, Stave R, Myren J, Osnes M, Hanssen L E, Mosvold J, Hebnes K
Scand J Gastroenterol. 1985 Dec;20(10):1246-8. doi: 10.3109/00365528509089284.
One hundred and seven consecutive patients with hematemesis and/or melena and a diagnosis of duodenal, gastric, or esophageal ulcers were interviewed immediately before or after endoscopy about the use of non-steroid anti-inflammatory drugs (NSAIDs) and symptoms before the hemorrhage. If the patients admitted no symptoms of abdominal pain or discomfort, nausea, vomiting, or heartburn, they were classified as having no ulcer symptoms before the hemorrhage. Patients who had not taken NSAIDs during the last 48 h before the hemorrhage were classified as not having taken NSAIDs. Significantly fewer patients had ulcer symptoms in the group that had used NSAIDs than in the other group (p less than 0.01). This may be interpreted as a possible masking effect by NSAIDs on ulcer symptoms. Physicians and patients should be aware of this possible effect of NSAIDs.
107例因呕血和/或黑便而被诊断为十二指肠、胃或食管溃疡的连续患者，在内镜检查之前或之后立即接受访谈，内容涉及非甾体抗炎药（NSAIDs）的使用情况以及出血前的症状。如果患者承认没有腹痛或不适、恶心、呕吐或烧心等症状，则被归类为出血前没有溃疡症状。在出血前最后48小时内未服用NSAIDs的患者被归类为未服用NSAIDs。使用NSAIDs的组中出现溃疡症状的患者明显少于另一组（p<0.01）。这可能被解释为NSAIDs对溃疡症状可能存在掩盖作用。医生和患者应意识到NSAIDs的这种可能影响。
