Nham Eliel, Jang A-Yeung, Hyun Hakjun, Yoon Jin Gu, Noh Ji Yun, Cheong Hee Jin, Kim Woo Joo, Ahn Ki Bum, Ji Hyun Jung, Seo Ho Seong, Bae Joon-Yong, Park Man-Seong, Song Joon Young
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Republic of Korea.
Vaccine Innovation Center-KU Medicine (VIC-K), Seoul 02841, Republic of Korea.
Vaccines (Basel). 2024 May 8;12(5):513. doi: 10.3390/vaccines12050513.
This is a cross-sectional serosurveillance study for RSV. Between June and September of 2021, a total of 150 sera were collected from 30 individuals in each age group (<5, 5-18, 19-49, 50-64, and ≥65 years). Seroprevalence was estimated using enzyme-linked immunosorbent assays targeting two stabilized prefusion F (preF; DS-Cav1 and SC-TM) and G proteins. The overall seroprevalence was low in young children and older adults, despite them having a higher risk of severe RSV infection. There was a remarkable difference in age-stratified seroprevalence rates between anti-preF and anti-G protein antibodies. Given the high disease burden and low seroprevalence in both infants and old adults, RSV vaccination would be crucial for pregnant women and people aged over 60 years.
这是一项针对呼吸道合胞病毒（RSV）的横断面血清学监测研究。在2021年6月至9月期间，从每个年龄组（<5岁、5 - 18岁、19 - 49岁、50 - 64岁和≥65岁）的30名个体中总共采集了150份血清。使用针对两种稳定的预融合F（preF；DS - Cav1和SC - TM）和G蛋白的酶联免疫吸附测定法估计血清阳性率。尽管幼儿和老年人发生严重RSV感染的风险较高，但其总体血清阳性率较低。抗preF和抗G蛋白抗体的年龄分层血清阳性率存在显著差异。鉴于婴儿和老年人的疾病负担高且血清阳性率低，RSV疫苗接种对于孕妇和60岁以上人群至关重要。
