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Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes.

作者信息

Davies A A, Cantrell D A, Crumpton M J

出版信息

Biosci Rep. 1985 Oct-Nov;5(10-11):867-76. doi: 10.1007/BF01119898.

DOI:10.1007/BF01119898
PMID:3879456
Abstract

Activators of protein kinase C induced a rapid decrease (within 15 min) in the surface expression of the T3 antigen and T-lymphocyte antigen receptor (Ti) on HPB-ALL cells, and a concomitant phosphorylation of the T3 gamma and delta polypeptides; the gamma chain was more extensively phosphorylated than the delta chain. No phosphorylation of the T3 epsilon chain and the Ti alpha and beta polypeptides was detected. Evidence was obtained that the T3 gamma chain is phosphorylated only on serine residues.

摘要

相似文献

1
Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes.
Biosci Rep. 1985 Oct-Nov;5(10-11):867-76. doi: 10.1007/BF01119898.
2
Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.蛋白激酶C激活剂可下调并磷酸化人T淋巴细胞的T3/T细胞抗原受体复合物。
Proc Natl Acad Sci U S A. 1985 Dec;82(23):8158-62. doi: 10.1073/pnas.82.23.8158.
3
T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes.T3糖蛋白在人T细胞受体γ T淋巴细胞上虽结构不同但仍具有功能。
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3817-21. doi: 10.1073/pnas.84.11.3817.
4
Association of phosphorylation of the T3 antigen with immune activation of T lymphocytes.
Nature. 1987;325(6104):540-2. doi: 10.1038/325540a0.
5
Activation-dependent phosphorylation of endogenous protein kinase C substrates in quiescent human T lymphocytes.静止期人T淋巴细胞内源性蛋白激酶C底物的激活依赖性磷酸化作用
Immunobiology. 1988 Mar;176(4-5):465-78. doi: 10.1016/s0171-2985(88)80027-5.
6
T3-p28 is a protein associated with the delta and epsilon chains of the T cell receptor-T3 antigen complex during biosynthesis.
J Biol Chem. 1987 Apr 5;262(10):4854-9.
7
The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation.
J Biol Chem. 1987 Aug 15;262(23):10918-21.
8
Evidence that a kinase distinct from protein kinase C induces CD3 gamma-subunit phosphorylation without a concomitant down-regulation in CD3 antigen expression.
J Immunol. 1989 Mar 1;142(5):1626-30.
9
The delta- and epsilon-chains of the human T3/T-cell receptor complex are distinct polypeptides.人类T3/T细胞受体复合物的δ链和ε链是不同的多肽。
Nature. 1984;312(5993):455-8. doi: 10.1038/312455a0.
10
Characterization of thymus-derived lymphocytes expressing Ti alpha-beta CD3 gamma delta epsilon zeta-zeta, Ti alpha-beta CD3 gamma delta epsilon eta-eta or Ti alpha-beta CD3 gamma delta epsilon zeta-zeta/zeta-eta antigen receptor isoforms: analysis by gene transfection.表达Tiα-β CD3γδϵζ-ζ、Tiα-β CD3γδϵη-η或Tiα-β CD3γδϵζ-ζ/ζ-η抗原受体亚型的胸腺来源淋巴细胞的特征：基因转染分析
J Exp Med. 1990 Oct 1;172(4):1243-53. doi: 10.1084/jem.172.4.1243.

引用本文的文献

1
Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation.T3-T细胞受体复合物的内吞作用与再循环。T3磷酸化的作用。
J Exp Med. 1987 Apr 1;165(4):1141-59. doi: 10.1084/jem.165.4.1141.
2
Phosphorylation of class I histocompatibility antigens in human B lymphocytes. Regulation by phorbol esters and insulin.人类B淋巴细胞中I类组织相容性抗原的磷酸化。佛波酯和胰岛素的调节作用。
Biochem J. 1988 Dec 15;256(3):763-8. doi: 10.1042/bj2560763.
3
Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits.
从cDNA序列推导的T3/T细胞抗原受体复合物T3γ亚基的一级结构：T3γ和δ亚基的进化
EMBO J. 1986 Aug;5(8):1799-808. doi: 10.1002/j.1460-2075.1986.tb04429.x.