School of Public Health, Guangzhou Medical University, Guangzhou 510180, China.
Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Nutrients. 2024 May 16;16(10):1507. doi: 10.3390/nu16101507.
Mounting evidence indicates a complex link between circulating saturated fatty acids (SFAs) and cardiovascular disease (CVD) risk factors, but research on erythrocyte membrane SFA associations with metabolic markers remains limited. Our study sought to investigate the correlations between erythrocyte membrane SFAs and key metabolic markers within glycemic and lipid metabolism in a Chinese population of 798 residents aged 41 to 71 from Guangzhou. Using gas chromatography-mass spectrometry, we assessed the erythrocyte membrane saturated fatty acid profile and performed multiple linear regression to evaluate the relationship between different SFA subtypes and metabolic markers. Our findings revealed that the odd-chain SFA group (C15:0 + C17:0) exhibited negative associations with fasting blood glucose (FBG), homeostatic model assessment for insulin resistance (HOMA-IR), and triglycerides (TG). Conversely, the very-long-chain SFA group (C20:0 + C22:0 + C23:0 + C24:0) exhibited positive associations with fasting insulins (FINS), HOMA-IR, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C). Furthermore, there was no evidence supporting an association between the even-chain group (C14:0 + C16:0 + C18:0) and metabolic markers. Our findings suggest that different subtypes of SFAs have diverse effects on glycemic and lipid metabolic markers, with odd-chain SFAs associated with a lower metabolic risk. However, the results concerning the correlations between even-chain SFAs and very-long-chain SFAs with markers of glycemic and lipid metabolism pathways are confusing, highlighting the necessity for further exploration and investigation.
越来越多的证据表明，循环饱和脂肪酸（SFAs）与心血管疾病（CVD）风险因素之间存在复杂的联系，但关于红细胞膜 SFA 与代谢标志物的关系的研究仍然有限。我们的研究旨在调查广州 798 名 41 至 71 岁居民的血糖和脂质代谢中红细胞膜 SFAs 与关键代谢标志物之间的相关性。我们使用气相色谱-质谱法评估了红细胞膜饱和脂肪酸谱，并进行了多元线性回归，以评估不同 SFA 亚型与代谢标志物之间的关系。我们的研究结果表明，奇数链 SFA 组（C15:0+C17:0）与空腹血糖（FBG）、胰岛素抵抗稳态模型评估（HOMA-IR）和三酰甘油（TG）呈负相关。相反，超长链 SFA 组（C20:0+C22:0+C23:0+C24:0）与空腹胰岛素（FINS）、HOMA-IR、总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）呈正相关。此外，没有证据表明偶数链组（C14:0+C16:0+C18:0）与代谢标志物之间存在关联。我们的研究结果表明，不同类型的 SFAs 对血糖和脂质代谢标志物有不同的影响，奇数链 SFAs 与较低的代谢风险相关。然而，偶数链 SFAs 与超长链 SFAs 与血糖和脂质代谢途径标志物之间的相关性结果令人困惑，这突出表明需要进一步探索和研究。
