白细胞介素21通过Blimp1的表达促进IgG1浆细胞分化，而非向IgE的类别转换。
Interleukin 21 promotes IgG1 plasma cell differentiation instead of class switching to IgE via Blimp1 expression.
作者信息
Hashiguchi Masaaki, Asatsuma-Okumura Tomoko, Iwai Yoshiko
机构信息
Department of Cell Biology, Institute for Advanced Medical Sciences, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
出版信息
Eur J Immunol. 2024 Aug;54(8):e2451041. doi: 10.1002/eji.202451041. Epub 2024 May 25.
PMID:38794862
Abstract
IgE is induced by the presence of IL-4 by class switching from IgM through IgG1 to IgE. IL-21 inhibits the IgE class switch by induction of Blimp1 leading to Stat6 and AID downregulation, and plasmablast/plasma cell differentiation.
摘要
白细胞介素-4的存在通过从IgM经IgG1向IgE的类别转换诱导产生IgE。白细胞介素-21通过诱导B淋巴细胞诱导成熟蛋白1，导致信号转导及转录激活因子6和活化诱导胞嘧啶脱氨酶下调，以及浆母细胞/浆细胞分化，从而抑制IgE类别转换。
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