Zhang Yan, Ren Yuanyuan, Li Xiaofang, Li Man, Fu Mingdi, Zhou Wenjing, Yu Yi, Xiong Yuyan
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an 710069, Shaanxi, PR China.
Department of Gastroenterology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi 710018, PR China.
Int J Biol Macromol. 2024 Jun;271(Pt 2):132473. doi: 10.1016/j.ijbiomac.2024.132473. Epub 2024 May 23.
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) serve as transcriptional co-activators that dynamically shuttle between the cytoplasm and nucleus, resulting in either the suppression or enhancement of their downstream gene expression. Recent emerging evidence demonstrates that YAP/TAZ is strongly implicated in the pathophysiological processes that contribute to cardiovascular diseases (CVDs). In the cardiovascular system, YAP/TAZ is involved in the orchestration of a range of biological processes such as oxidative stress, inflammation, proliferation, and autophagy. Furthermore, YAP/TAZ has been revealed to be closely associated with the initiation and development of various cardiovascular diseases, including atherosclerosis, pulmonary hypertension, myocardial fibrosis, cardiac hypertrophy, and cardiomyopathy. In this review, we delve into recent studies surrounding YAP and TAZ, along with delineating their roles in contributing to the pathogenesis of CVDs with a link to various physiological processes in the cardiovascular system. Additionally, we highlight the current potential drugs targeting YAP/TAZ for CVDs therapy and discuss their challenges for translational application. Overall, this review may offer novel insights for understanding and treating cardiovascular disorders.
Yes相关蛋白（YAP）和具有PDZ结合基序的转录共激活因子（TAZ）作为转录共激活因子，在细胞质和细胞核之间动态穿梭，导致其下游基因表达受到抑制或增强。最近出现的证据表明，YAP/TAZ与导致心血管疾病（CVD）的病理生理过程密切相关。在心血管系统中，YAP/TAZ参与一系列生物过程的协调，如氧化应激、炎症、增殖和自噬。此外，YAP/TAZ已被揭示与各种心血管疾病的发生和发展密切相关，包括动脉粥样硬化、肺动脉高压、心肌纤维化、心脏肥大和心肌病。在这篇综述中，我们深入探讨了围绕YAP和TAZ的最新研究，同时阐述了它们在导致CVD发病机制中的作用，并与心血管系统中的各种生理过程建立联系。此外，我们强调了目前针对CVD治疗的靶向YAP/TAZ的潜在药物，并讨论了它们在转化应用中的挑战。总体而言，这篇综述可能为理解和治疗心血管疾病提供新的见解。
