Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Diabetes Res Clin Pract. 2024 Jun;212:111718. doi: 10.1016/j.diabres.2024.111718. Epub 2024 May 24.
We compared performance of high 1-hour PG level, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) in predicting type 2 diabetes in a longitudinal community-based cohort of Hong Kong Chinese.
Between 2001 and 2003, 472 adults aged 18-55 years without diabetes underwent 75-gram oral glucose tolerance test (OGTT). Between 2012 and 2014, progression to diabetes was ascertained by reviewing medical records or repeating OGTT and HbA. We defined high 1-hour PG as PG ≥ 8.6 mmol/L at 1-hour.
In this cohort, 23.5% had normal glucose tolerance and high 1-hour PG, 10.0% had isolated IGT, 4.2% had isolated IFG. Over 12-year follow-up, 9.3% developed type 2 diabetes. In logistic regression, high 1-hour PG was associated with progression to type 2 diabetes with adjusted odds ratio (95% CI) of 4.20 (1.60, 12.40), independent of IFG, IGT and other clinical variables. Areas under ROC (95% CI) for type 2 diabetes were similar between 1-hour (0.84 [0.78, 0.89], 2-hour (0.79 [0.72, 0.86]) and fasting PG (0.79 [0.71, 0.86]).
High 1-hour PG identified young Chinese with 5-fold increased risk of type 2 diabetes independent of other intermediate hyperglycaemia status and clinical factors. 1-hour PG is similar to fasting and 2-hour PG in predicting type 2 diabetes.
我们比较了高 1 小时 PG 水平、空腹血糖受损（IFG）和葡萄糖耐量受损（IGT）在预测香港华人纵向社区队列 2 型糖尿病中的表现。
在 2001 年至 2003 年期间，472 名年龄在 18-55 岁之间、无糖尿病的成年人接受了 75 克口服葡萄糖耐量试验（OGTT）。在 2012 年至 2014 年期间，通过审查医疗记录或重复 OGTT 和 HbA 来确定糖尿病的进展情况。我们将高 1 小时 PG 定义为 1 小时 PG≥8.6mmol/L。
在该队列中，23.5%的人糖耐量正常且 1 小时 PG 升高，10.0%的人孤立性 IGT，4.2%的人孤立性 IFG。在 12 年的随访中，9.3%的人发展为 2 型糖尿病。在逻辑回归中，高 1 小时 PG 与 2 型糖尿病的进展相关，调整后的优势比（95%CI）为 4.20（1.60，12.40），独立于 IFG、IGT 和其他临床变量。2 型糖尿病的 ROC 曲线下面积（95%CI）在 1 小时（0.84 [0.78, 0.89]、2 小时（0.79 [0.72, 0.86]）和空腹 PG（0.79 [0.71, 0.86]）之间相似。
高 1 小时 PG 可识别出患 2 型糖尿病风险增加 5 倍的年轻中国人，与其他中间高血糖状态和临床因素无关。1 小时 PG 在预测 2 型糖尿病方面与空腹和 2 小时 PG 相似。
