Price P
J Clin Lab Immunol. 1978 Nov;1(3):261-8.
Responses to two or more antigens given together or separated by an interval of up to four days were determined in young mice maintained from weaning on a 4% albumin diet, and compared with those of normally-fed controls. Simultaneous challenge with several antigens did not affect antibody production in mice of either dietary group ("Simultaneous Competition") and the responses of normal and protein-deficient mice to sheep or rat erythrocytes were similarly produced by the prior injection of horse or sheep cells ("Sequential Competition"). However, the low protein diet broadened the conditions under which primary and secondary injections of diphtheria toxoid impaired primary responses to tetanus toxoid. These findings are discussed in relation to mechanisms previously proposed to explain antigenic competition, with a view to explaining the effects of protein-deficiency on antibody production.
在从断奶起就以4%白蛋白饮食饲养的幼鼠中，测定了对同时给予或间隔至多四天给予的两种或更多种抗原的反应，并与正常喂养的对照组进行了比较。同时用几种抗原进行攻击并不影响任何一个饮食组小鼠的抗体产生（“同时竞争”），正常小鼠和蛋白质缺乏小鼠对绵羊或大鼠红细胞的反应，通过预先注射马或绵羊细胞也同样产生（“相继竞争”）。然而，低蛋白饮食拓宽了白喉类毒素初次和二次注射损害对破伤风类毒素初次反应的条件。结合先前提出的解释抗原竞争的机制对这些发现进行了讨论，以解释蛋白质缺乏对抗体产生的影响。
