School of Medicine, Royal College of Surgeons in Ireland, Building No. 2441, Road 2835, Busaiteen 228, Bahrain.
Yale College, New Haven, CT, USA.
Dermatol Clin. 2024 Jul;42(3):471-480. doi: 10.1016/j.det.2024.02.011. Epub 2024 Apr 10.
Cytokine blocking therapies have revolutionized the management of psoriasis and atopic dermatitis but can lead to the development of paradoxic psoriasis (PP). Patients treated with biologics should be closely monitored for the development of PP and other paradoxical eruptions (including inflammatory joint disease, inflammatory bowel disease, eczematous eruptions, lupus like eruptions, sarcoidal eruptions, and others) and occasionally the development of cutaneous T-cell lymphoma. Further understanding the immunologic mechanism of these processes will ultimately drive our understanding of and ability to predict and manage PPs.
细胞因子阻断疗法彻底改变了银屑病和特应性皮炎的治疗方法，但也可能导致出现矛盾性银屑病（PP）。使用生物制剂治疗的患者应密切监测 PP 及其他矛盾性发疹（包括炎症性关节病、炎症性肠病、湿疹样发疹、狼疮样发疹、类肉瘤样发疹等）和偶尔出现的皮肤 T 细胞淋巴瘤的发展情况。进一步了解这些过程的免疫机制将最终推动我们对 PP 的认识和预测及管理能力。
