产时使用抗生素与儿童 4 岁时的体重指数（BMI）z 评分较高有关。
Intrapartum antibiotic use is associated with higher child body mass index (BMI) z-score at 4 years of age.
机构信息
Facuty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.
Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Psychology, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute (ACHRI), University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
出版信息
Obes Res Clin Pract. 2024 May-Jun;18(3):222-225. doi: 10.1016/j.orcp.2024.05.002. Epub 2024 May 24.
Early life antibiotic exposure may increase obesity risk. We investigated if prenatal, intrapartum, or childhood antibiotic use is associated with child zBMI score at 4 yrs of age. We included data from the Alberta Pregnancy Outcomes and Nutrition (APrON) study, a prospective cohort study, on maternal and child antibiotic exposure and clinic measures of height and weight at age 4 (n = 408). Prenatal and childhood antibiotic exposure was not associated with zBMI score. Maternal intrapartum antibiotic exposure was associated with a zBMI score increase of 0.12 (95 % CI; 0.04, 0.46) in children at 4 years of age compared to non-exposure intrapartum.
早期抗生素暴露可能会增加肥胖风险。我们研究了产前、产时或儿童时期使用抗生素是否与 4 岁儿童 zBMI 评分相关。我们纳入了来自艾伯塔省妊娠结局和营养（APrON）研究的数据，这是一项前瞻性队列研究，研究了母亲和儿童的抗生素暴露情况，以及 4 岁时诊所测量的身高和体重（n=408）。产前和儿童时期使用抗生素与 zBMI 评分无相关性。与无产时抗生素暴露相比，母亲产时使用抗生素与儿童 4 岁时 zBMI 评分增加 0.12（95%CI：0.04，0.46）相关。
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