Tipisova E V, Zyabisheva V N, Alikina V A, Elfimova A E, Molodovskaya I N
N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Science.
Probl Endokrinol (Mosk). 2023 Jun 6;70(2):11-22. doi: 10.14341/probl13286.
Knowledge of the physiological mechanisms of adaptation arising in response to changes in photoperiods is especially important for residents of the European North. In the literature, there is practically no information about photoperiodic dynamics of serum dopamine level, despite its significant role in the regulation of the body's activity. The mutual modulating effect of the dopaminergic and thyroid systems is known.
To show the ratio of dopamine levels and the content of hormones, protines and autoantibodies of the thyroid system, taking into account photoperiod of the year, in practically healthy populations of the European North.
Healthy male population (20 men) of Arkhangelsk was examined in various photoperiods of the year (80 samples): an increase in the length of daylight hours (March), its maximum duration (June), a decrease (September), and a minimum duration (December). The inhabitants of the settlements and the nomadic aboriginal population (100 men) were examined during 2 photoperiods of the year - March and December. The serum levels of iodothyronines, TSH, TG, antibodies to TPO, antibodies to TG and plasma level of dopamine were determined using ELISA methods.
Residents of Arkhangelsk in June compared to December have higher levels of dopamine (0.502 and 0.365 nmol/l, p=0.01), T3 (1.09 and 0.94 nmol/l, p=0.003), T4 (113.45 and 99.03 nmol/l, p=0.0002). In September, compared with June, a decrease in dopamine (0.235 nmol/l, p=0.0003), T3 (0.92 nmol/l, p=0.004) was recorded with an increase in T4/T3 ratio from 106.54 to 117.89 units (p=0.006). The nomadic aboriginal population in March compared with December showed a tendency to a higher content of dopamine (0.00 and 0.394 nmol/l, p=0.07) with the decrease in fT4 (15.20 and 13.90, p=0.015), fT4/fT3 ratio from 3.13 to 2.28 units (p=0.006). In December, 67% of nomadic population had undetectable dopamine values (0 nmol/l) and 22% - excess dopamine values, in March 27% - excess values.
Unidirectional changes in dopamine and thyroid activity in men of the European North were shown with their decrease during periods of decrease and minimum daylight hours and an increase during periods of increase and maximum daylight hours.
了解因光周期变化而产生的生理适应机制，对欧洲北部的居民尤为重要。尽管血清多巴胺水平在调节身体活动中发挥着重要作用，但在文献中，几乎没有关于其光周期动态变化的信息。已知多巴胺能系统和甲状腺系统存在相互调节作用。
在欧洲北部实际健康人群中，考虑一年中的光周期，展示多巴胺水平与甲状腺系统激素、蛋白质和自身抗体含量的比值。
对阿尔汉格尔斯克的健康男性人群（20名男性）在一年中的不同光周期（80个样本）进行检查：日照时长增加（3月）、日照时长最长（6月）、日照时长减少（9月）和日照时长最短（12月）。对定居点居民和游牧原住民人群（100名男性）在一年中的两个光周期——3月和12月进行检查。使用酶联免疫吸附测定法测定血清中碘甲状腺原氨酸、促甲状腺激素、甲状腺球蛋白、抗甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体水平以及血浆多巴胺水平。
与12月相比，阿尔汉格尔斯克的居民在6月时多巴胺水平更高（分别为0.502和0.365纳摩尔/升，p = 0.01）、T3水平更高（分别为1.09和0.94纳摩尔/升，p = 0.003）、T4水平更高（分别为113.45和99.03纳摩尔/升，p = 0.0002）。与6月相比，9月时多巴胺水平下降（0.235纳摩尔/升，p = 0.0003）、T3水平下降（0.92纳摩尔/升，p = 0.004），T4/T3比值从106.54升至117.89单位（p = 0.006）。与12月相比，游牧原住民人群在3月时多巴胺含量有升高趋势（分别为0.00和0.394纳摩尔/升，p = 0.07），游离T4水平下降（分别为15.2和13.90，p = 0.015），游离T4/游离T3比值从3.13降至2.28单位（p = 0.006）。12月时，67%的游牧人群多巴胺值检测不到（0纳摩尔/升），22%的人群多巴胺值过高；3月时，27%的人群多巴胺值过高。
欧洲北部男性的多巴胺和甲状腺活动呈现单向变化，在日照时长减少和最短期间下降，在日照时长增加和最长期间升高。
