Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine, USA.
Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine, USA.
Curr Opin Pharmacol. 2024 Jun;76:102464. doi: 10.1016/j.coph.2024.102464. Epub 2024 May 25.
Glycation is a posttranslational modification of proteins that contributes to the vast array of biological information that can be conveyed via a singular proteome. Understanding the role of advanced glycation end-products (AGEs) in human health and pathophysiology can be difficult, as the physiological effects of AGEs have been associated with multiple biological processes and disease state development, including acute myocardial ischemia-reperfusion injury, heart failure, and atherosclerosis, as well as tumor cell migration. The critical role of the glyoxalase system in the detoxification of methylglyoxal and other AGEs has been well established. Recently, evidence has emerged that DJ-1 displays antiglycative activity and may contribute to another mechanism of protection against protein glycation outside of the glyoxalase system. Identification of potential substrates of DJ-1 and determination of the pathways in which DJ-1 operates, is needed to fully understand the role of this protein in modulating biological homeostasis and the development of disease.
糖基化是蛋白质的一种翻译后修饰，它为通过单一蛋白质组传递的大量生物学信息做出贡献。理解晚期糖基化终产物（AGEs）在人类健康和病理生理学中的作用可能很困难，因为 AGEs 的生理效应与多种生物学过程和疾病状态的发展有关，包括急性心肌缺血再灌注损伤、心力衰竭和动脉粥样硬化，以及肿瘤细胞迁移。糖氧还蛋白系统在清除甲基乙二醛和其他 AGEs 中的解毒作用已得到充分证实。最近的证据表明，DJ-1 具有抗糖化活性，并且可能有助于糖氧还蛋白系统之外的另一种防止蛋白质糖化的保护机制。确定 DJ-1 的潜在底物，并确定 DJ-1 发挥作用的途径，对于充分理解该蛋白在调节生物学动态平衡和疾病发展中的作用是必要的。
