College of Traditional Chinese Medicine, Shandong Second Medical University, Weifang 261053, China.
First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
Biomed Pharmacother. 2024 Jul;176:116783. doi: 10.1016/j.biopha.2024.116783. Epub 2024 May 25.
During tumor development, the tumor itself must continuously generate new blood vessels to meet their growth needs while also allowing for tumor invasion and metastasis. One of the most common features of tumors is hypoxia, which drives the process of tumor angiogenesis by regulating the tumor microenvironment, thus adversely affecting the prognosis of patients. In addition, to overcome unsuitable environments for growth, such as hypoxia, nutrient deficiency, hyperacidity, and immunosuppression, the tumor microenvironment (TME) coordinates angiogenesis in several ways to restore the supply of oxygen and nutrients and to remove metabolic wastes. A growing body of research suggests that tumor angiogenesis and hypoxia interact through a complex interplay of crosstalk, which is inextricably linked to the TME. Here, we review the TME's positive contribution to angiogenesis from an angiogenesis-centric perspective while considering the objective impact of hypoxic phenotypes and the status and limitations of current angiogenic therapies.
在肿瘤发展过程中，肿瘤本身必须不断产生新的血管以满足其生长需求，同时也允许肿瘤侵袭和转移。肿瘤最常见的特征之一是缺氧，它通过调节肿瘤微环境来驱动肿瘤血管生成过程，从而对患者的预后产生不利影响。此外，为了克服生长不适宜的环境，如缺氧、营养缺乏、酸中毒和免疫抑制，肿瘤微环境（TME）通过多种方式协调血管生成，以恢复氧气和营养物质的供应，并清除代谢废物。越来越多的研究表明，肿瘤血管生成和缺氧通过复杂的相互作用相互作用，这与 TME 密不可分。在这里，我们从血管生成为中心的角度回顾 TME 对血管生成的积极贡献，同时考虑缺氧表型的客观影响以及当前血管生成治疗的现状和局限性。
