Cancer Biology Division, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University (Institute of Eminence), Campus-11, Patia, Bhubaneswar, Odisha Pin-751024, India.
Cancer Treat Rev. 2024 Jun;127:102749. doi: 10.1016/j.ctrv.2024.102749. Epub 2024 May 1.
Cancer cells merely exist in isolation; rather, they exist in an intricate microenvironment composed of blood vessels, signalling molecules, immune cells, stroma, fibroblasts, and the ECM. The TME provides a setting that is favourable for the successful growth and survivance of tumors. Angiogenesis is a multifaceted process that is essential for the growth, invasion, and metastasis of tumors. TME can be visualized as a "concert hall," where various cellular and non-cellular factors perform in a "symphony" to orchestrate tumor angiogenesis and create "Havoc" instead of "Harmony". In this review, we comprehensively summarized the involvement of TME in regulating tumor angiogenesis. Especially, we have focused on immune cells and their secreted factors, inflammatory cytokines and chemokines, and their role in altering the TME. We have also deciphered the crosstalk among various cell types that further aids the process of tumor angiogenesis. Additionally, we have highlighted the limitations of existing anti-angiogenic therapy and discussed various potential strategies that could be used to overcome these challenges and improve the efficacy of anti-angiogenic therapy.
癌细胞仅仅是孤立存在的；相反，它们存在于一个由血管、信号分子、免疫细胞、基质、成纤维细胞和细胞外基质组成的复杂微环境中。TME 为肿瘤的成功生长和存活提供了有利的环境。血管生成是肿瘤生长、侵袭和转移所必需的一个多方面的过程。TME 可以被看作是一个“音乐厅”，其中各种细胞和非细胞因素以“交响乐”的形式协同作用，协调肿瘤血管生成，并制造“混乱”而不是“和谐”。在这篇综述中，我们全面总结了 TME 在调节肿瘤血管生成中的作用。特别是，我们关注了免疫细胞及其分泌因子、炎症细胞因子和趋化因子，以及它们在改变 TME 中的作用。我们还破译了各种细胞类型之间的串扰，这进一步促进了肿瘤血管生成的过程。此外，我们强调了现有抗血管生成治疗的局限性，并讨论了各种潜在的策略，这些策略可以用来克服这些挑战，提高抗血管生成治疗的疗效。
