Doctoral School, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen, Germany.
Aging Cell. 2024 Jul;23(7):e14208. doi: 10.1111/acel.14208. Epub 2024 May 26.
Anti-aging research has made significant strides in identifying treatments capable of extending lifespan across a range of organisms, from simple invertebrates to mammals. This review showcases the current state of anti-aging interventions, highlighting the lifespan extensions observed in animal models through various treatments and the challenges encountered in translating these findings to humans. Despite promising results in lower organisms, the translation of anti-aging treatments to human applications presents a considerable challenge. This discrepancy can be attributed to the increasing complexity of biological systems, species-specific metabolic and genetic differences, and the redundancy of metabolic pathways linked to longevity. Our review focuses on analyzing these challenges, offering insights into the efficacy of anti-aging mechanisms across species and identifying key barriers to their translation into human treatments. By synthesizing current knowledge and identifying gaps in translatability, this review aims to underscore the importance of advancing these therapies for human benefit. Bridging this gap is essential to assess the potential of such treatments in extending the human healthspan.
抗衰老研究在鉴定能够延长从简单无脊椎动物到哺乳动物等一系列生物寿命的治疗方法方面取得了重大进展。本综述展示了当前抗衰老干预措施的现状，强调了通过各种治疗方法在动物模型中观察到的寿命延长，并讨论了将这些发现转化为人类应用所面临的挑战。尽管在低等生物中取得了有希望的结果，但将抗衰老治疗转化为人类应用仍然面临着相当大的挑战。这种差异可以归因于生物系统的复杂性不断增加、物种特异性的代谢和遗传差异以及与长寿相关的代谢途径的冗余性。我们的综述重点分析了这些挑战，探讨了跨物种抗衰老机制的疗效，并确定了将其转化为人类治疗的关键障碍。通过综合当前的知识并确定可转化性的差距，本综述旨在强调推进这些疗法以造福人类的重要性。弥合这一差距对于评估这些治疗方法在延长人类健康寿命方面的潜力至关重要。
