白细胞介素-1β基因多态性对肝癌微血管门静脉侵犯及预后的影响。

Effect of genetic polymorphisms of interleukin-1 beta on the microscopic portal vein invasion and prognosis of hepatocellular carcinoma.

机构信息

Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

出版信息

J Hepatobiliary Pancreat Sci. 2024 Aug;31(8):528-536. doi: 10.1002/jhbp.12009. Epub 2024 May 26.

DOI:10.1002/jhbp.12009

PMID:38798075

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11503458/

Abstract

BACKGROUND

Several studies have demonstrated a relationship between genetic polymorphisms of interleukin-1 beta (IL-1β) and cancer development; however, their influence on cancer prognosis is unknown. In the present study, we aimed to evaluate the impact of IL-1β single nucleotide polymorphisms on the hematogenous dissemination and prognosis of hepatocellular carcinoma.

METHODS

We conducted a retrospective cohort study including patients with hepatocellular carcinoma who underwent primary liver resection at our hospital between April 2015 and December 2018. The primary endpoints were overall and recurrence-free survival. Secondary endpoints were microscopic portal vein invasion and number of circulating tumor cells.

RESULTS

A total of 148 patients were included, 32 with rs16944 A/A genotype. A/A genotype was associated with microscopic portal vein invasion and number of circulating tumor cells (p = .03 and .04). In multivariate analysis, A/A genotype, alpha-fetoprotein level, and number of circulating tumor cells were associated with microscopic portal vein invasion (p = .01, .01, and <.01). A/A genotype, Child-Pugh B, and intraoperative blood loss were independent predictive factors for overall survival (p = .02, <.01, and <.01).

CONCLUSIONS

Our results indicate that the IL-1β rs16944 A/A genotype is involved in number of circulating tumor cells, microscopic portal vein invasion, and prognosis in HCC.

摘要

背景

多项研究表明白细胞介素-1β（IL-1β）基因多态性与癌症的发生发展有关，但它们对癌症预后的影响尚不清楚。本研究旨在评估 IL-1β 单核苷酸多态性对肝细胞癌血行播散和预后的影响。

方法

我们进行了一项回顾性队列研究，纳入了 2015 年 4 月至 2018 年 12 月在我院接受原发性肝切除术的肝细胞癌患者。主要终点为总生存期和无复发生存期。次要终点为镜下门静脉侵犯和循环肿瘤细胞数。

结果

共纳入 148 例患者，其中 rs16944 A/A 基因型 32 例。A/A 基因型与镜下门静脉侵犯和循环肿瘤细胞数有关（p=0.03 和.04）。多变量分析显示，A/A 基因型、甲胎蛋白水平和循环肿瘤细胞数与镜下门静脉侵犯有关（p=0.01、.01 和 <.01）。A/A 基因型、Child-Pugh B 分级和术中出血量是总生存期的独立预测因素（p=0.02、<.01 和 <.01）。