Abddelgader Rasha M, Karamooz Sarvenaz, Choi Hosoon, Hwang Munok, Jinadatha Chetan, Navarathna Dhammika H
Department of Pathology and Laboratory Medicine, Baylor Scott & White Medical Center, Temple, TX, USA.
Department of Research, Central Texas Veterans Health Care System, Temple, TX, USA.
IDCases. 2024 May 17;36:e01985. doi: 10.1016/j.idcr.2024.e01985. eCollection 2024.
We investigated a skin abscess caused by in a patient with comorbidities. Initial empirical therapy with Clindamycin did not yield a response, and follow-up culture revealed the presence of through MALDI-TOF and NGS. Since no CLSI or FDA breakpoints have been published for this strain, resistant gene screening of the genetic sequence showed the presence of the erm(X) gene (with 95 % identity). This gene confers resistance to erythromycin, clindamycin, lincomycin, pristinamycin, quinupristin, and virginiamycin. Subsequent therapy with oral amoxicillin/clavulanate led to complete healing.
我们对一名患有合并症患者身上由[未提及的病原体]引起的皮肤脓肿进行了调查。最初使用克林霉素进行经验性治疗未见效果，后续培养通过基质辅助激光解吸电离飞行时间质谱（MALDI-TOF）和二代测序（NGS）检测出[未提及的病原体]。由于针对该菌株尚未公布临床和实验室标准协会（CLSI）或美国食品药品监督管理局（FDA）的断点，对基因序列进行耐药基因筛查显示存在erm(X)基因（同一性为95%）。该基因赋予对红霉素、克林霉素、林可霉素、普那霉素、奎奴普丁和维吉尼亚霉素的耐药性。随后口服阿莫西林/克拉维酸治疗使脓肿完全愈合。
Zotero 插件