异基因造血干细胞移植后患者中耐多药单纯疱疹病毒1型的再激活：通过下一代测序动态检测罕见的A605V突变
Reactivation of Multidrug-Resistant HSV-1 in a Post-Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing.
作者信息
Zheng Shuxuan, Rümke Lidewij L W, Tello Rubio Bruno, Rogers Malbert R C, van Sluis Geerte L, Kuball Jürgen H E, Riezebos-Brilman Annelies, Lebbink Robert Jan, Verduyn Lunel Frans M
机构信息
Department of Medical Microbiology, UMC Utrecht, Utrecht, The Netherlands.
Department of Haematology UMC Utrecht, Utrecht, The Netherlands.
出版信息
Open Forum Infect Dis. 2024 May 3;11(5):ofae250. doi: 10.1093/ofid/ofae250. eCollection 2024 May.
We present an immunocompromised patient with a multiresistant herpes simplex virus-1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.
我们报告了一名免疫功能低下患者，其单纯疱疹病毒1型发生多药耐药性再激活，病毒DNA聚合酶基因存在罕见突变（A605V）。二代测序表明，治疗前存在多种耐药菌株，治疗期间比例发生变化，影响了对阿昔洛韦和膦甲酸钠的临床反应。
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