尼日利亚黑人中非糖尿病患者和2型糖尿病患者对蹲姿压力的心血管反应
Cardiovascular Responses to Squatting Postural Stress among Non-Diabetic and Type-2 Diabetic Nigerian Black Africans.
作者信息
Aiku Abimbola Olufunmilayo, Adagbada Ebunoluwa Oluwabusola, Ogbonna Samson Ndubuisi, Fasanmade Adesoji Adedipe
机构信息
Department of Physiology, University of Ibadan, Nigeria.
出版信息
Niger Med J. 2022 Sep 10;63(1):35-42. doi: 10.60787/NMJ-63-1-100. eCollection 2022 Jan-Feb.
BACKGROUND
A change in posture brings about a significant alteration in cardiovascular functions. The squat test has been used to study autonomic function in White Europeans but not Black Africans. The aim of this study is to determine the cardiovascular effects of postural stress in Black African non-diabetics and Type-2 diabetics.
METHOD
Blood pressure (BP) and heart rate (HR) was measured in 40 non-diabetics and 40Type-2 diabetics in sitting, standing from sitting, squatting and standing from squatting positions Difference in BP and HR between consecutive positions was tested using 2- way mixed ANOVA. Proportions of those who showed orthostatic hypotension and hypertension were compared with Fishers exact test. Significance was set at p <0.05.
MMHG Δ: BP and HR changes evoked by standing from sitting were not different, however squatting evoked greater increase in BP in diabetics(change (Δ) SBP: 5.85±9.95 vs 17.40±13.75mmHg: Δ DBP: 0.15 ± 6.89 vs 5.10 ± 7.59 mmHg:Δ MABP:2.02 ± 6.98 vs 8.63 ± 9.34 mmHg ,p <0.05) and standing from squatting evoked greater fall BP in diabetics (ΔSBP: -9.80±13.89 vs -24.35±16.03 mmHg; Δ MABP:-2.02±6.98 vs -8.63±9.34 mmHg: Δ PP: -2.28 ±15.35 vs -14.50 ±11.96 mmHg, p < 0.05) while Δ HR did not differ. A higher proportion of diabetics showed SBP and DBP orthostatic hypertension.
CONCLUSION
Relative to the non-diabetics, diabetics showed greater BP but not HR responses to postural stress.
背景
姿势的改变会引起心血管功能的显著变化。深蹲试验已被用于研究欧洲白人的自主神经功能，但尚未用于研究非洲黑人。本研究的目的是确定姿势应激对非洲黑人非糖尿病患者和2型糖尿病患者的心血管影响。
方法
对40名非糖尿病患者和40名2型糖尿病患者在坐位、从坐位站立、蹲位以及从蹲位站立时的血压（BP）和心率（HR）进行测量。使用双向混合方差分析检验连续体位之间BP和HR的差异。使用Fisher精确检验比较出现体位性低血压和高血压患者的比例。显著性设定为p<0.05。
毫米汞柱变化值
从坐位站立引起的BP和HR变化没有差异，然而，蹲位引起糖尿病患者的BP升高幅度更大（收缩压变化（Δ）：5.85±9.95 vs 17.40±13.75mmHg；舒张压变化：0.15±6.89 vs 5.10±7.59mmHg；平均动脉压变化：2.02±6.98 vs 8.63±9.34mmHg，p<0.05），并且从蹲位站立引起糖尿病患者的BP下降幅度更大（收缩压变化：-9.80±13.89 vs -24.35±16.03mmHg；平均动脉压变化：-2.02±6.98 vs -8.63±9.34mmHg；脉压变化：-2.28±15.35 vs -14.50±11.96mmHg，p<0.05），而心率变化没有差异。更高比例的糖尿病患者出现收缩压和舒张压体位性高血压。
结论
与非糖尿病患者相比，糖尿病患者对姿势应激的血压反应更大，但心率反应无差异。
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