Mishra N, Mahajan K K
Department of Physiology, Medical College, Rohtak.
J Indian Med Assoc. 1996 Jan;94(1):3-5.
Cardiovascular responses to cold pressor test (CPT) followed by orthostatic stress were investigated in diabetics and in control subjects. The test was performed by immersing the left hand (up to wrist joint) in water at 8 degrees C for 2 minutes. The blood pressure (BP) and heart rate (HR) were recorded immediately after removal of hand from water in recumbent state and then in erect posture. The orthostatic stress (without cold exposure) caused postural hypotension in diabetics, while in control subjects BP (both systolic and diastolic) increased on attaining erect posture. CPT alone increased HR, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in control as well as in diabetics. In control subjects when CPT was followed by orthostatic stress, a marked statistically significant further increase in HR but fall in SBP was observed, though the increase in DBP was not significant. On the other hand statistically significant increase in HR, and decrease in SBP, DBP were observed in diabetic subjects. These impairments in cardiovascular responses are confirmative of autonomic neuropathy in diabetic subjects.
对糖尿病患者和对照受试者进行了冷加压试验（CPT）后再施加直立应激的心血管反应研究。试验方法是将左手（至腕关节）浸入8摄氏度的水中2分钟。在受试者从水中取出手后立即记录其仰卧位和直立位的血压（BP）和心率（HR）。直立应激（无冷暴露）在糖尿病患者中导致体位性低血压，而在对照受试者中，达到直立姿势时血压（收缩压和舒张压）升高。单独的CPT在对照组和糖尿病患者中均增加了心率、收缩压（SBP）和舒张压（DBP）。在对照受试者中，CPT后再施加直立应激时，观察到心率有明显的统计学显著进一步增加，但收缩压下降，尽管舒张压的增加不显著。另一方面，在糖尿病受试者中观察到心率有统计学显著增加，收缩压和舒张压下降。这些心血管反应的损害证实了糖尿病患者存在自主神经病变。
