Babaei Kosar, Aziminezhad Mohsen, Mirzajani Ebrahim, Mozdarani Hossein, Sharami Seyedeh Hajar, Norollahi Seyedeh Elham, Samadani Ali Akbar
Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
UMR INSERM U 1122, IGE-PCV, Interactions Gène-Environment En Physiopathologie Cardiovascular Université De Lorraine, Nancy, France.
Toxicol Rep. 2024 May 9;12:546-563. doi: 10.1016/j.toxrep.2024.05.001. eCollection 2024 Jun.
Recurrent pregnancy Loss (RPL)is a frequent and upsetting condition. Besides the prevalent cause of RPL including chromosomal defects in the embryo,the effect of translational elements like alterations of epigenetics are of great importance. The emergence of epigenetics has offered a fresh outlook on the causes and treatment of RPL by focusing on the examination of DNA methylation. RPL may arise as a result of aberrant DNA methylation of imprinted genes, placenta-specific genes, immune-related genes, and sperm DNA, which may have a direct or indirect impact on embryo implantation, growth, and development. Moreover, the distinct immunological tolerogenic milieu established at the interface between the mother and fetus plays a crucial role in sustaining pregnancy. Given this, there has been a great deal of interest in the regulation of DNA methylation and alterations in the cellular components of the maternal-fetal immunological milieu. The research on DNA methylation's role in RPL incidence and the control of the mother-fetal immunological milieu is summed up in this review.
复发性流产（RPL）是一种常见且令人苦恼的病症。除了RPL的常见病因，如胚胎染色体缺陷外，表观遗传学改变等翻译元件的影响也非常重要。表观遗传学的出现通过关注DNA甲基化检查，为RPL的病因和治疗提供了新的视角。RPL可能是由于印记基因、胎盘特异性基因、免疫相关基因和精子DNA的异常DNA甲基化导致的，这可能对胚胎着床、生长和发育产生直接或间接影响。此外，在母胎界面建立的独特免疫耐受环境在维持妊娠中起着关键作用。鉴于此，人们对DNA甲基化的调节以及母胎免疫环境细胞成分的改变产生了浓厚兴趣。本综述总结了DNA甲基化在RPL发病机制中的作用以及对母胎免疫环境的调控。
