Nishimura T, Hiromatsu K, Takashima T, Tabuki K, Kotani Y
Jpn J Antibiot. 1979 Sep;32(9):890-900.
The authors have carried out the laboratory and clinical studies of cefamandole (CMD). The results are as follows: The sensitivity was measured by plate dilution method on 26 strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and 14 strains of Salmonella typhimurium isolated from patients. The distribution of sensitivity of S. aureus was 0.39 approximately 3.13 micrograms/ml and the peak of distribution was 1.56 micrograms/ml. The distribution of sensitivity of E. coli was 0.78 approximately greater than 100 micrograms/ml, and K. pneumoniae, 1.56 approximately greater than 100 micrograms/ml. The distribution of sensitivity of Salmonella typhimurium was 6.25 approximately greater than 100 micrograms/ml and its peak was 6.25 micrograms/ml. CMD were given intravenously for 30 and 60 minutes at a single dose of 25 mg/kg body weight to 6 children. The serum mean levels of CMD were 105.3 micrograms/ml at 30 minutes, 15.1 micrograms/ml at 1.5 hours, 1.6 micrograms/ml at 2.5 hours after drip infusion for 30 minutes, respectively, and 34.7, 5.2, 0.6 micrograms/ml at 1, 2, 3 hours after drip infusion for 60 minutes, respectively. And the serum level at 4 hours after administration was not detected. The mean urinary excretion rates were 73.3% in the drip infusion for 30 minutes and 60.7% in its for 60 minutes, up to 8 hours after administration. Half life was 26 minutes. CMD was effective in 18 of 21 cases of bacterial infections. No side effects were observed except for 2 cases with elevation of serum transaminase.
作者进行了头孢孟多（CMD）的实验室和临床研究。结果如下：采用平板稀释法对从患者分离出的26株金黄色葡萄球菌、大肠杆菌、肺炎克雷伯菌以及14株鼠伤寒沙门氏菌进行敏感性测定。金黄色葡萄球菌的敏感性分布为0.39至约3.13微克/毫升，分布峰值为1.56微克/毫升。大肠杆菌的敏感性分布为0.78至约大于100微克/毫升，肺炎克雷伯菌为1.56至约大于100微克/毫升。鼠伤寒沙门氏菌的敏感性分布为6.25至约大于100微克/毫升，其峰值为6.25微克/毫升。对6名儿童以25毫克/千克体重的单次剂量静脉注射CMD 30分钟和60分钟。静脉滴注30分钟后，CMD的血清平均水平在30分钟时为105.3微克/毫升，1.5小时时为15.1微克/毫升，2.5小时时为1.6微克/毫升；静脉滴注60分钟后，在1、2、3小时时分别为34.7、5.2、0.6微克/毫升。给药后4小时未检测到血清水平。给药后长达8小时，静脉滴注30分钟时的平均尿排泄率为73.3%，静脉滴注60分钟时为60.7%。半衰期为26分钟。在21例细菌感染病例中，CMD对18例有效。除2例血清转氨酶升高外，未观察到副作用。
