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Teaching an Old Dog New Tricks for Achieving CB-Selective Inverse Agonism.

作者信息

Mando Morgane, Cunningham Christopher W, Grenning Alexander J

机构信息

Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Department of Pharmaceutical Sciences, Concordia University Wisconsin, Mequon, Wisconsin 53097, United States.

出版信息

ACS Cent Sci. 2024 May 8;10(5):946-948. doi: 10.1021/acscentsci.4c00673. eCollection 2024 May 22.

DOI:10.1021/acscentsci.4c00673
PMID:38799666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11117306/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/11117306/3ebc49a888b1/oc4c00673_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/11117306/3ebc49a888b1/oc4c00673_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/11117306/3ebc49a888b1/oc4c00673_0001.jpg

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本文引用的文献

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Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists.翻转GPCR开关：基于结构的选择性大麻素受体2反向激动剂的开发
ACS Cent Sci. 2024 Mar 11;10(5):956-968. doi: 10.1021/acscentsci.3c01461. eCollection 2024 May 22.
2
Axially Chiral Cannabinoids: Design, Synthesis, and Cannabinoid Receptor Affinity.轴向手性大麻素：设计、合成与大麻素受体亲和力。
J Am Chem Soc. 2023 Jun 28;145(25):13581-13591. doi: 10.1021/jacs.3c00129. Epub 2023 Jun 14.
3
Structural basis of selective cannabinoid CB receptor activation.
选择性大麻素 CB 受体激活的结构基础。
Nat Commun. 2023 Mar 15;14(1):1447. doi: 10.1038/s41467-023-37112-9.
4
Molecular switches in GPCRs.G 蛋白偶联受体中的分子开关。
Curr Opin Struct Biol. 2019 Apr;55:114-120. doi: 10.1016/j.sbi.2019.03.017. Epub 2019 May 10.
5
Chromenopyrazole-based High Affinity, Selective Fluorescent Ligands for Cannabinoid Type 2 Receptor.基于色烯并吡唑的大麻素2型受体高亲和力、选择性荧光配体
ACS Med Chem Lett. 2019 Jan 30;10(2):209-214. doi: 10.1021/acsmedchemlett.8b00597. eCollection 2019 Feb 14.
6
Crystal Structure of the Human Cannabinoid Receptor CB2.人源大麻素受体 CB2 的晶体结构
Cell. 2019 Jan 24;176(3):459-467.e13. doi: 10.1016/j.cell.2018.12.011. Epub 2019 Jan 10.
7
Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment.基于烷基吲哚的大麻素 2 型受体工具：连接子和荧光团连接的探索。
Eur J Med Chem. 2018 Feb 10;145:770-789. doi: 10.1016/j.ejmech.2017.11.076. Epub 2017 Nov 28.
8
Uptake, distribution and diffusivity of reactive fluorophores in cells: implications toward target identification.细胞内反应荧光团的摄取、分布和扩散：对靶标识别的影响。
Mol Pharm. 2010 Aug 2;7(4):1301-10. doi: 10.1021/mp100089k.
9
HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor.HU - 308：一种外周大麻素受体CB(2)的特异性激动剂。
Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14228-33. doi: 10.1073/pnas.96.25.14228.