Thakare Piyush, Prakash Nilima L, Mahajan Aarti M, Bhadage Chetan J
Department of Oral and Maxillofacial Surgery, M.G.V's K.B.H. Dental College and Hospital, Nashik, Maharashtra, India.
Department of Oral Pathology and Microbiology, M.G.V's K.B.H. Dental College and Hospital, Nashik, Maharashtra, India.
J Oral Maxillofac Pathol. 2024 Jan-Mar;28(1):142-145. doi: 10.4103/jomfp.jomfp_205_23. Epub 2024 Apr 15.
The central giant cell granuloma displays a varied biologic behaviour ranging from simple reactive lesions to aggressive neoplasms. The pathogenicity still remains enigmatic and needs to be differentiated from other giant cell containing lesions. Both maxilla and mandible are affected and 80% involve the region anterior to the first premolar region. CGCL arises centrally within bone, whereas PGCG is a gingival soft tissue lesion. Clinical and radiographic correlation is required to rule out a peripheral giant cell granuloma. The case described here was a rare presentation of a large epulis clinically with involvement of maxilla radiographically and was histologically diagnosed as a central giant cell lesion.
中央巨细胞肉芽肿表现出多样的生物学行为，范围从简单的反应性病变到侵袭性肿瘤。其发病机制仍然不明，需要与其他含有巨细胞的病变相鉴别。上颌骨和下颌骨均可受累，80%累及第一前磨牙区前方区域。中央型巨细胞病变发生于骨中央，而外周型巨细胞病变是牙龈软组织病变。需要临床与影像学相结合以排除外周型巨细胞肉芽肿。本文所述病例是临床上罕见的巨大龈瘤表现，影像学显示上颌骨受累，组织学诊断为中央巨细胞病变。
